Acta Med. 2006, 49: 59-65
https://doi.org/10.14712/18059694.2017.111
The Model of D-Galactosamine-Induced Injury of Rat Hepatocytes in Primary Culture
References
1. T, Shinozuka H, Fearber E. Inhibition of protein synthesis in rat liver by D-galactosamine. Res Commun Chem Pathol Pharmacol 1973; 5:481–91.
2. Berry MN, Edwards AM, Barritt GJ. Isolated hepatocytes preperation, properties and application. In: Burdon RH, van Knippenberg PH, eds. Elsevier, New York, Oxford, Amsterdam, 1991:15–81.
3. RK, Grunwald R, Lemasters JJ. Rhodamine 123 as a probe of transmembrane potential in isolated rat-liver mitochondria: spectral and metabolic properties. Biochim Biophys Acta 1986; 850:436–48.
<https://doi.org/10.1016/0005-2728(86)90112-X>
4. H, Zidek Z, Hynie S. Effects of nitroprusside as a nitric oxide donor on anoxia/reoxygenation and D-galactosamine hepatic injuries: a study in perfused hepatocytes. Physiol Res 1997; 46:363–9.
5. PJ, Hilf R. A fluorometric method for determination of oxidized and reduced glutathione in tissues. Anal Biochem. 1976; 74:214–26.
<https://doi.org/10.1016/0003-2697(76)90326-2>
6. S, Sonaka I, Fujitani S, Nishiguchi S. Mechanisms of the protective effect of L-alanine to D-galactosamine-induced hepatocellular injury: comparative studies of L-alanine and pyruvate. Biochem Biophys Res Commun 2002; 291:738–43.
<https://doi.org/10.1006/bbrc.2002.6508>
7. D, Lesch R, Reutter W, Decker K. Experimental hepatitis induced by D-galactosamine. Exp Mol Pathol 1968; 9:279–90.
<https://doi.org/10.1016/0014-4800(68)90042-7>
8. D, Rudigier J, Bischoff E, Decker K. The trapping of uridine phosphates by D-galactosamine, D-glucosamine, and 2–deoxy-D-galactose. Eur J Biochem 1970; 17:246–53.
<https://doi.org/10.1111/j.1432-1033.1970.tb01160.x>
9. D, Pausch J, Decker K. Selective uridine triposphate deficiency induced by D-galactosamine in liver and reversed by pyrimidine nucleotide precursors: Effect on ribonucleic acid synthesis. J Biol Chem 1974; 249:211–16.
10. JJ, Nieminen AL, Qian T, Trost LC, Elmore SP, Nishimura Y, Crowe RA, Cascio WE, Bradham CA, Brenner DA, Herman B. The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy. Biochim Biophys Acta. 1998; 1366:177–96.
<https://doi.org/10.1016/S0005-2728(98)00112-1>
11. JR, Gandolfi AJ, Sipes IG. Cystamine modulation of galactosamineinduced hepatotoxicity. Toxicol Appl Pharmacol 1984; 73:551–58.
<https://doi.org/10.1016/0041-008X(84)90107-8>
12. JR, Gandolfi AJ, Sipes IG. Hepatic cysteamine and nonprotein sulfhydryl levels following cystamine or cysteamine treatment of galactosamine-poisoned rats. Drug Chem Toxicol 1985; 8:483–94.
<https://doi.org/10.3109/01480548509041071>
13. Y, Nakayama S, Horie T. Role of mitochondrial permeability transition in diclofenac-induced hepatocyte injury in rats. Hepatology 2002; 35:544–51.
<https://doi.org/10.1053/jhep.2002.31871>
14. JM, Jollow DJ. Galactosamine Hepatotoxixity: Effect of galactosamine on glutathione resynthesis in rat primary hepatocyte cultures. Toxicol Appl Pharmacol 1992; 115:234–40.
<https://doi.org/10.1016/0041-008X(92)90328-P>
15. JM. Galactosamine decreases nitric oxide formation in cultured rat hepatocytes: Lack of involvement in cytotoxicity. J Biochem Toxicol 1999; 13: 143–8.
<https://doi.org/10.1002/(SICI)1099-0461(1999)13:3/4<143::AID-JBT4>3.0.CO;2-0>
16. A, Pedraza CA, Siendones E et al. PGE1 protection against apoptosis induced by D-galactosamine is not related to the modulation of intracellular free radical production in primary culture of rat hepatocytes. Free Radic Res 2002; 36:345–55.
<https://doi.org/10.1080/10715760290019372>
17. E, Fouad D, Abou-Elella A, Quintero A, Barrera P, Muntané J. Role of nitric oxide in D-galactosamine.induced cell death and its protection by PGE1 in cultured hepatocytes. Nitric Oxide 2003; 8:133–43.
<https://doi.org/10.1016/S1089-8603(02)00182-9>
18. R, Seabra V, Bradford B et al. Glycine and uridine prevent D-galactosamine hepatotoxicity in the rat: Role of Kupffer cells. Hepatology 1999; 29:737–45.
<https://doi.org/10.1002/hep.510290335>
19. F, Hamagawa E, Tsutsui Ch et al. Evaluation of oxidative stress during apoptosis and necrosis caused by D-galactosamine in rat liver. Biochem Pharmacol 2003; 65:101–7.
<https://doi.org/10.1016/S0006-2952(02)01420-X>
20. T, Furukawa Y, Murakami M, Takemura S, Kondo M. Effects of vitamin E on D-galactosamine-induced or carbon tetrachloride-induced hepatotoxicity. Digestion 1982; 25:222–9.
<https://doi.org/10.1159/000198836>


