Transplantation of Bone Marrow Derived Progenitor Cells in Acute Myocardial Infarction. The First Results

Pudil, Radek; Vojáček, Jan; Filip, Stanislav; Měřička, Pavel; Šťásek, Josef; Straková, Hana; Vokurková, Doris; Solař, Miroslav; Mokrý, Jaroslav; Dominik, Jan; Malý, Jaroslav

doi:10.14712/18059694.2018.44

Acta Medica > Archive > 2005, Vol. 48 > Issue 3-4 > Transplantation of Bone Marrow Derived…

Acta Med. 2005, 48: 153-155

https://doi.org/10.14712/18059694.2018.44

Transplantation of Bone Marrow Derived Progenitor Cells in Acute Myocardial Infarction. The First Results

Radek Pudil^a, Jan Vojáček^a, Stanislav Filip^b, Pavel Měřička^c, Josef Šťásek^a, Hana Straková^b, Doris Vokurková^d, Miroslav Solař^a, Jaroslav Mokrý^e, Jan Dominik^f, Jaroslav Malý^g

^aCharles University Prague, Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, 1st Department of Medicine, Hradec Králové, Czech Republic
^bCharles University Prague, Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Department of Oncology and Radiology, Hradec Králové, Czech Republic
^cCharles University Prague, Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Tissue Bank, Hradec Králové, Czech Republic
^dCharles University Prague, Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Department of Clinical Immunology and Allergology, Hradec Králové, Czech Republic
^eCharles University Prague, Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Department of Histology and Embryology, Hradec Králové, Czech Republic
^fCharles University Prague, Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Department of Cardiosurgery, Hradec Králové, Czech Republic
^gCharles University in Prague, Faculty of Medicine and University Hospital Hradec Králové, 2nd Department of Medicine, Hradec Králové, Czech Republic

Received February 1, 2005
Accepted May 1, 2005

The intracoronary administration of autologous bone marrow cells (BMCs) has been shown to improve the left ventricle function in the course of acute myocardial infarction. Therefore we have started a clinical trial using transplantation of BMCs in the acute phase of myocardial infarction. The aim of our study is to assess the feasibility and safety of this procedure, and effect on the left ventricle function of these patients. We describe the first experience in two patients with acute myocardial infarction reperfused using direct stenting. The aspiration of bone marrow from the sternum provided sufficient amount of the cells for transplantation. No serious ischemia and no changes in coronary artery patency were detected after intracoronary infusion. The left ventricle ejection fraction was increasing throughout the time of three-month follow-up. No other complications (ventricular arrhythmias, reinfarction, thrombus formation) were detected.

Keywords

Myocardial infarction, Bone marrow cells, Progenitor cells, Ejection fraction.

Funding

The study was supported by the research project MZO 00179906 and Cardiovascular Research Project of the Charles University Prague, No. MSM 0021620817 „Invasive approach to myocardial salvage and regeneration“.