Acta Med. 2005, 48: 87-90

https://doi.org/10.14712/18059694.2018.37

The Influence of the Time of Antidotal Treatment Administration on the Potency of Newly Developed Oximes to Counteract Acute Toxic Effects of Tabun in Mice

Jiří Kassa

University of Defence in Brno, Faculty of Military Health Sciences in Hradec Králové, Department of Toxicology, Hradec Králové, Czech Republic

Received February 1, 2005
Accepted May 1, 2005

References

1. Bajgar J, Fusek J, Vachek J. Treatment and prophylaxis against nerve agent poisoning. ASA Newslett 1994; 94(4):10–1.
2. Cabal J, Bajgar J. Tabun – návrat po padesáti letech. Chem Listy 1999; 93:27–31.
3. Clement JG, Shiloff JD, Gennings C. Efficacy of a combination of acetylcholinesterase reactivators, HI-6 and obidoxime, against tabun and soman poisoning in mice. Arch Toxicol 1987; 61:70–5. <https://doi.org/10.1007/BF00324551>
4. Dawson RM. Review of oximes available for the treatment of nerve agent poisoning. J Appl Toxicol 1994; 14:317–31. <https://doi.org/10.1002/jat.2550140502>
5. Eto M. Organophosphorus pesticides: Organic and biological chemistry. Cleveland: CRC Press Inc, 1976:142.
6. Jokanovic M. Anticholinesterase activity and delayed neurotoxic effects of tabun in hens. Vojvosanit Pregl 1993; 50:451–56.
7. Jokanovic M, Maksimovic M, Kilibarda V, Jovanovic D, Savic D. Oxime-induced reactivation of acetylcholinesterase inhibited by phosphoramidates. Toxicol Lett 1996; 85:35–9. <https://doi.org/10.1016/0378-4274(96)03634-X>
8. Kassa J. A comparison of the therapeutic efficacy of conventional and modern oximes against supralethal doses of highly toxic organophosphates in mice. Acta Med (Hradec Králové) 1998; 41(1):19–21.
9. Kassa J. Vliv doby podání antidotní terapie na její účinnost vůči toxicitě somanu u myší. Voj zdrav Listy 1999; 68(4):93–5.
10. Kassa J. Review of oximes in the antidotal treatment of poisoning by organophosphorus nerve agents. J Toxicol–Clin Toxicol 2002; 40(6):803–16. <https://doi.org/10.1081/CLT-120015840>
11. Kassa J. Vliv dávky reaktivátorů acetylcholinesterázy na jejich účinnost při terapii otravy myší tabunem. Čes Slov Farm 2004; 53(1):31–4.
12. Kassa J. The influence of the time of antidotal treatment administration on its effectiveness against tabun-induced poisoning in mice. Acta Med (Hradec Králové) 2004; 47(2):111–4.
13. Kassa J, Vachek J. A comparison of the efficacy of pyridostigmine alone and the combination of pyridostigmine with anticholinergic drugs as pharmacological pretreatment of tabun-poisoned rats and mice. Toxicology 2002; 177:179–85. <https://doi.org/10.1016/S0300-483X(02)00219-6>
14. Koplovitz I, Menton R, Matthews C, Shutz M, Nalls C, Kelly C. Dose-response effects of atropine and HI-6 treatment of organophosphorus poisoning in guinea pigs. Drug Chem Toxicol 1995; 18:119–36. <https://doi.org/10.3109/01480549509014316>
15. Kuča K, Bielavský J, Cabal J, Bielavská M. Synthesis of a potential reactivator of acetylcholinesterase – 1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium)propane dibromide. Tetrahedron Lett 2003; 44: 3123–5. <https://doi.org/10.1016/S0040-4039(03)00538-0>
16. Kuča K, Bielavský J, Cabal J, Kassa J. Synthesis of a new reactivator of tabun-inhibited acetylcholinesterase. Bioorg Med Chem Lett 2003; 13: 3545–7. <https://doi.org/10.1016/S0960-894X(03)00751-0>
17. Kuča K, Kassa J. A comparison of the ability of a new bispyridinium oxime – 1-(4-hydroxyiminomethylpyridinium)-4-(4carbamoylpyridinium)butane dibromide and currently used oximes to reactivate nerve agent-inhibited rat brain acetylcholinesterase by in vitro methods. J Enzyme Inhib Med Chem 2003; 18(6):529–35. <https://doi.org/10.1080/14756360310001605552>
18. Kuča K, Kassa J. In vitro reactivation of acetylcholinesterase using the oxime K027. Vet Hum Toxicol 2004; 46(1):15–8.
19. Marrs TC. Organophosphate poisoning. Pharmacol Ther 1993; 58:51–66. <https://doi.org/10.1016/0163-7258(93)90066-M>
20. Ohtomi S, Takase M, Kumagai F. Sarin poisoning in Japan. A clinical experience in Japan Self Defense Force (JSDF) Central Hospital. Int Rev Arm Ser 1996; 69:97–102.
21. Puu G, Artursson E, Bucht G. Reactivation of nerve agent inhibited acetylcholinesterases by HI-6 and obidoxime. Biochem Pharmacol 1986; 35:1505–10. <https://doi.org/10.1016/0006-2952(86)90116-4>
22. Tallarida R, Murray R. Manual of pharmacological calculation with computer programs. New York: Springer-Verlag, 1987:145.
23. Taylor P. Anticholinesterase agents. In: The pharmacological basis of therapeutics (Hardman JG, Lombird LE eds.) New York: McGraw Hill, 1996:161–76.
24. Worek F, Widmann R, Knopff O, Szinicz L. Reactivating potency of obidoxime, pralidoxime, HI-6 and Hlö-7 in human erythrocyte acetylcholinesterase inhibited by highly toxic organophosphorus compounds. Arch Toxicol 1998; 72: 237–43. <https://doi.org/10.1007/s002040050495>
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