Acta Med. 2005, 48: 81-86
https://doi.org/10.14712/18059694.2018.36
A Comparison of the Potency of the Oxime HLö-7 and Currently Used Oximes (HI-6, Pralidoxime, Obidoxime) to Reactivate Nerve Agent-Inhibited Rat Brain Acetylcholinesterase by in vitro Methods
References
1. J, Fusek J, Vachek J. Treatment and prophylaxis against nerve agent poisoning. ASA Newslett 1994; 94–4:10–1.
2. J, Kuča K, Kassa J. Specification of the structure of oximes able to reactivate tabun-inhibited acetylcholinesterase. Pharmacol Toxicol 2004; 95:81–6.
<https://doi.org/10.1111/j.1742-7843.2004.950207.x>
3. RM. Review of oximes available for treatment of nerve agent poisoning. J Appl Toxicol 1994; 14:317–31.
<https://doi.org/10.1002/jat.2550140502>
4. Eto M. Organophosphorus pesticides: organic and biological chemistry. Cleveland: CRC Press Inc., 1976:342.
5. RH, Leadbeater L. The efficacy of bispyridinium derivatives in the treatment of organophosphonate poisoning in the guinea pig. J Pharm Pharmacol 1983; 35:427–33.
<https://doi.org/10.1111/j.2042-7158.1983.tb04316.x>
6. M., Maksimovic M, Kilibarda V, Jovanovic D, Savic D. Oxime-induced reactivation of acetylcholinesterase inhibited by phosphoramidates. Toxicol Lett 1996; 85:35–9.
<https://doi.org/10.1016/0378-4274(96)03634-X>
7. J. Review of oximes in the antidotal treatment of poisoning by organophosphorus nerve agents. J Toxicol–Clin Toxicol 2002; 40:803–16.
<https://doi.org/10.1081/CLT-120015840>
8. J, Cabal J. A comparison of the efficacy of a new asymmetric bispyridinium oximes BI-6 with currently available oximes and H oximes against soman by in vitro and in vivo methods. Toxicology 1999; 132:111–8.
<https://doi.org/10.1016/S0300-483X(98)00146-2>
9. J, Cabal J. A comparison of the efficacy of acetylcholinesterase reactivators against cyclohexyl methylphosphonofluoridate (GF agent) by in vitro and in vivo methods. Pharmacol Toxicol 1999; 84:41–5.
<https://doi.org/10.1111/j.1600-0773.1999.tb02109.x>
10. I, Stewart JR. A comparison of the efficacy of HI-6 and 2–PAM against soman, sarin and VX in the rabbit. Toxicol Lett 1995; 70:269–79.
<https://doi.org/10.1016/0378-4274(94)90121-X>
11. K, Kassa J. A comparison of the ability of a new bispyridinium oxime – 1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium) butane dibromide and currently used oximes to reactivate nerve agent-inhibited rat brain acetylcholinesterase by in vitro methods. J Enzyme Inhib Med Chem 2003; 18:529–35.
<https://doi.org/10.1080/14756360310001605552>
12. K, Kassa J. Oximes-induced reactivation of rat brain acetylcholinesterase inhibited by VX agent. Hum Exp Toxicol 2004; 23:167–71.
<https://doi.org/10.1191/0960327104ht434oa>
13. K, Patočka J, Cabal J. Reactivation of organophosphate inhibited acetylcholinesterase activity by α,ω-bis-(4-hydroxyiminomethylpyridinium) alkanes in vitro. J Appl Biomed 2003; 1:207–11.
14. TC. Organophosphate poisoning. Pharmacol Ther 1993; 58:51–66.
<https://doi.org/10.1016/0163-7258(93)90066-M>
15. T-M. Comparison of several oximes on reactivation of soman-inhibited blood, brain and tissue cholinesterase activity in rats. Arch Toxicol 1993; 67:637–46.
<https://doi.org/10.1007/BF01974071>
16. L, Kuča K, Krejčová G, Vachek J. Therapeutic efficacy of oxime treatment in cyclosarin-poisoned mice pretreated with a combination of pyridostigmine, benactyzine and trihexyphenidyle. J Appl Biomed 2004; 2:163–7.
17. Taylor, P. Anticholinesterase agents. In: J.G. Hardman, L.E. Lombird (eds.): The pharmacological basis of therapeutics. New York, McGraw Hill:1996: pp. 161–76.
18. EIC, Braid PE. Oxime reactivation of diethylphosphoryl human serum cholinesterase. J Biol Chem 1967; 242:2683–7.
19. F, Widmann R, Knopff O, Szinicz, L. Reactivating potency of obidoxime, pralidoxime, HI-6 and Hlö-7 in human erythrocyte acetylcholinesterase inhibited by highly toxic organophosphorus compounds. Arch Toxicol 1998; 72:237–43.
<https://doi.org/10.1007/s002040050495>
