Acta Med. 2004, 47: 171-175
https://doi.org/10.14712/18059694.2018.86
Assessment of the Therapeutic and Anticonvulsive Efficacy of a Drug Combination Consisting of Trihexyphenidyle and HI-6 in Soman-Poisoned Rats
References
1. J. Present view on toxidynamics of soman poisoning. Acta Med (Hradec Králové) 1996; 39:101–5.
2. J, Fusek J, Vachek J. Treatment and prophylaxis against nerve agent poisoning. ASA Newslett 1994; 94:10–1.
3. J, Patočka J, Herink J, Fusek J, Hrdina V. Effect of benactyzine, atropine and chlorpromazine on blood-brain barrier permeability in rats. Activ Nerv Sup 1978; 20:56–62.
4. RM. Review of oximes available for the treatment of nerve agent poisoning. J Appl Toxicol 1994; 14:317–31.
<https://doi.org/10.1002/jat.2550140502>
5. EHJr, Nikaido AM, Gupta SK, Heatherly DG, Nishita JK. Comparison of central nervous system and peripheral pharmacodynamics to atropine pharmacokinetics. J Pharmacol Exp Ther 1990; 255:1133–41.
6. JH, Harris LW. Dealkylation as a mechanism for aging of cholinesterase after poisoning with pinacolyl methylphosphonofluoridate. Biochem Pharmacol 1965; 14:641–9.
<https://doi.org/10.1016/0006-2952(65)90082-1>
7. T, Raveh L, Cohen G et al. Distribution of 3H-soman in mice. Arch Toxicol 1985; 58:45–9.
<https://doi.org/10.1007/BF00292616>
8. J. Importance of cholinolytic drug selection for the efficacy of HI-6 against soman in rats. Toxicology 1997; 116:147–52.
<https://doi.org/10.1016/S0300-483X(96)03537-8>
9. J, Fusek J. The influence of anticholinergic drug selection on the efficacy of antidotal treatment of soman poisoned rats. Toxicology 2000; 154:67–73.
<https://doi.org/10.1016/S0300-483X(00)00322-X>
10. J, Fusek J. The influence of oxime selection on the efficacy of antidotal treatment of soman poisoned rats. Acta Med (Hradec Králové) 2002; 45:19–27.
11. S, Ishizaki F, Yamamura Y, Khoriyama T, Kito S. Effects of anticholinergic antiparkinsonic drugs on binding of muscarinic receptor subtypes in rat brain. Res Commun Chem Pathol Pharmacol 1990; 69:261–7.
12. I, Menton R, Matthew C, Shutz M, Nalls C, Kelly S. Dose-response effects of atropine and HI-6 treatment of organophosphorus poisoning in guineapigs. Drug Chem Toxicol 1995; 18:119–31.
<https://doi.org/10.3109/01480549509014316>
13. TC. Organophosphate poisoning. Pharmacol Ther 1993; 58:51–66.
<https://doi.org/10.1016/0163-7258(93)90066-M>
14. JHJr, Shih T-M. Neuropharmacological mechanisms of nerve agentinduced seizure and neuropathology. Neurosci Biobehav Rev 1997; 21:559–79.
<https://doi.org/10.1016/S0149-7634(96)00050-4>
15. E, Ishizaki J, Takeda M, Matsushita R, Yokogawa K, Ichimura F. Pharmacodynamics of anticholinergic drugs and brain muscarinic receptor alteration in streptozotoxin diabetic rats. Biopharm Drug Dispos 1993; 14:673–8.
<https://doi.org/10.1002/bdd.2510140804>
16. S, Takase M, Kumagai F. Sarin poisoning in Japan. A clinical experience in Japan Self Defense Force (JSDF) Central Hospital. Int Rev Arm Ser 1996; 69:97–102.
17. JM. Soman neurotoxicity. Fundam Appl Toxicol 1983; 1:73–83.
18. M, Langenberg JP, Benschop H. New method for retrospective detection of exposure to organophosphorus anticholinesterases: application to alleged sarin victims of Japanese terrorists. Toxicol Appl Pharmacol 1997; 146:156–61.
<https://doi.org/10.1006/taap.1997.8243>
19. I. Efficacy of biperiden and HI-6 as prophylactic combination against convulsions produced by highly toxic organophosphorus compounds. Voj zdrav Listy 2001; 70(Suppl 1):30–2.
20. TM. Comparison of several oximes on reactivation of soman-inhibited blood, brain and tissue cholinesterase activity in rats. Arch Toxicol 1993; 67:637–46.
<https://doi.org/10.1007/BF01974071>
21. Tallarida R, Murray R. Manual of pharmacological calculation with computer programs. New York: Springer-Verlag, 1987:145.
22. J, Kassa J, Fusek J, Bajgar J. Novější způsoby léčby intoxikace organofosfáty. Sbor věd Prací VLA JEP (Hradec Králové) 1993; 116:67–95.
23. K, Nakashima E, Ishizaki J, Hasegawa M, Kido H, Ichimura F. Brain regional pharmacokinetics of biperiden in rats. Biopharm Drug Dispos 1992; 13:131–8.
<https://doi.org/10.1002/bdd.2510130207>


