Acta Med. 2004, 47: 167-169
https://doi.org/10.14712/18059694.2018.85
1,3–Bis(2–hydroxyiminomethylpyridinium) Propane as the Potential Reactivator of the Acetylcholinesterase Inhibited by Nerve Agents
References
1. WK, Davies DR, Green AL. Oximes of α,ω-diquaternary alkane salts as antidotes to organophosphate anticholinesterases. Brit J Pharmacol 1959; 14: 186–91.
2. J, Kassa J, Elsnerová E, Dejmek L. Cholinesterase reactivators derived from pyridine-2–carbaldoxime. Collect Czech Chem Commun 1997; 63:199–204.
<https://doi.org/10.1135/cccc19980199>
3. J, Kassa J, Patočka J. Inhibition of plasma cholinesterase by O-alkylfluorophosphonates. Collect Czech Chem Commun 1996; 62:521–6.
<https://doi.org/10.1135/cccc19970521>
4. J. Review of oximes in the antidotal treatment of poisoning by organophosphorus nerve agents. J Toxicol Clin Toxicol 2002; 40:803–16.
<https://doi.org/10.1081/CLT-120015840>
5. K, Bielavský J, Cabal J, Bielavska M. Synthesis of a potential reactivator of acetylcholinesterase – 1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium)-propane dibromide. Tetrahedron Lett 2003; 44:3123–5.
<https://doi.org/10.1016/S0040-4039(03)00538-0>
6. K, Bielavský J, Cabal J, Kassa J. Synthesis of a New Reactivator of tabuninhibited acetylcholinesterase. Bioorg Med Chem Lett 2003; 13:3545–7.
<https://doi.org/10.1016/S0960-894X(03)00751-0>
7. K, Cabal J, Patočka J, Kassa J. Synthesis of bisquaternary symmetric – χ,δ-bis(2–hydroxyiminomethylpyridinium)alkane dibromides and their reactivation of cyclosarin-inhibited acetylcholinesterase. Lett Org Chem 2004; 1:84–6.
<https://doi.org/10.2174/1570178043488761>
8. K, Kassa J. A comparison of the ability of a new byispyridinium oxime – 1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium)butane dibromide and currently used oximes to reactivate nerve agent-inhibited rat brain acetylcholinesterase by in vitro methods. J Enzyme Inhib Med Chem 2003; 18:529–35.
<https://doi.org/10.1080/14756360310001605552>
9. K, Patočka J, Cabal J. Reactivation of organophosphate inhibited acetylcholinesterase activity by α,ω-bis-(4-hydroxyiminomethylpyridinium)alkanes in vitro. J Appl Biomed 2003; 1:207–11.
10. TC. Organophosphate poisoning. Pharmacol Therap 1993; 58:51–66.
<https://doi.org/10.1016/0163-7258(93)90066-M>
11. I, Bielavský J. An overview of syntheses of cholinesterase reactivators from 1980 to 1992. Voj Zdrav Listy 2001; 70:63–73 (in Czech).
12. K, Hampl F, Liška F, Cabal J, Patočka J. Sustituted pyridinium derivatives as inhibitors of acetylcholinesterase. Voj Zdrav Listy – Suplementum 1998; 67:28–31.
