Altered Intrahepatic Hematopoiesis in Neonates from Women with Pregnancy Induced Hypertension/Pre-Eclampsia

Tamiolakis, Demetrio; Venizelos, Ioannis; Lambropoulou, Maria; Efthymiadou, Anna; Arvanitidou, Vasiliki; Tsikouras, Panagiotis; Koutsougeras, Gerasimos; Chimonis, George; Karamanidis, Demetrio; Barbagadaki, Sophia; Nikolaidou, Sylva; Seliniotaki, Evagelia; Boglou, Panagiotis; Papadopoulos, Nikolas

doi:10.14712/18059694.2018.76

Acta Medica > Archive > 2004, Vol. 47 > Issue 2 > Altered Intrahepatic Hematopoiesis in…

Acta Med. 2004, 47: 119-123

https://doi.org/10.14712/18059694.2018.76

Altered Intrahepatic Hematopoiesis in Neonates from Women with Pregnancy Induced Hypertension/Pre-Eclampsia

Demetrio Tamiolakis^a, Ioannis Venizelos^b, Maria Lambropoulou^c, Anna Efthymiadou^c, Vasiliki Arvanitidou^c, Panagiotis Tsikouras^d, Gerasimos Koutsougeras^e, George Chimonis^e, Demetrio Karamanidis^e, Sophia Barbagadaki^a, Sylva Nikolaidou^a, Evagelia Seliniotaki^a, Panagiotis Boglou^c, Nikolas Papadopoulos^c

^aGeneral Hospital of Chania, Department of Cytology, Greece
^bIppokration Hospital of Salonica, Department of Pathology, Greece
^cDemocritus University of Thrace, Department of Histology–Embryology, Greece
^dDemocritus University of Thrace, Department of Obstetrics and Gynecology, Greece
^eGeneral Hospital of Alexandroupolis, Department of Obstetrics and Gynecology, Greece

Received January 1, 2004
Accepted March 1, 2004

Aim: To detect whether preeclampsia influences neonatal intrahepatic hematopoiesis, given that an activation of fetal neutrophils and monocytes during the course of this disorder occurs. Experimental design: We examined liver samples from 10 neonates of hypertensive/preeclamptic women at 27 to 28 weeks of gestation delivered by a cessarian section. All neonates were placed in incubators but they all died within 24 hours due to immaturity. The control group comprised 10 fetuses of the same gestational age, after voluntary abortion due to a neural defect. Specific antibodies against CD34, glycophorin C, hemoglobins A and F, myeloperoxidase, CD61, CD68, terminal desoxynucleotidyl transferase and the pax-5/B-cell specific activator protein, were used in each sample. Results: Neonates from hypertensive/preeclamptic women, in comparison with controls, showed: a statistically significant reduction of erythropoiesis by 25% (p=0.015); a statistically significant increase of granulopoiesis (p=0.019); a statistically significant increase in the expression of CD68 positive cells of the monocytic lineage (p=0.017); a statistically significant increase in the expression of CD34 progenitor/stem positive cells (p=0.021). No statistically significant differences were observed in both examined groups, concerning megakaryopoiesis and B lymphopoiesis. Conclusions: Preeclampsia of pregnancy has an impact on neonatal intrahepatic hematopoiesis by increasing granulopoiesis, reducing erythropoiesis and triggering endothelial and stem cell activation. We suggest that these findings reflect a state of persistent inflammation and a loss of red blood cell production possibly contributing to the neonatal morbidity related to this disorder.