Acta Med. 2004, 47: 107-109

https://doi.org/10.14712/18059694.2018.73

In Vitro Reactivation of Acetylcholinesterase Inhibited by Cyclosarin Using Bisquaternary Pyridinium Aldoximes K005, K033, K027 and K048

Kamil Kuča, Lucie Ševelová-Bartošová, Gabriela Krejčová-Kunešová

Purkyně Military Medical Academy, Department of Toxicology, Hradec Králové, Czech Republic

Received February 1, 2004
Accepted April 1, 2004

References

1. Cabal J, Bajgar J. Tabun – Reappearance 50 years later. Chem Listy 1999; 93: 27–9. (in Czech)
2. Dohnal V, Kuča K, Havel J, Cabal J. Prediction of novel structures of efficient reactivators of cyclosarin-inhibited acetylcholinesterase using method of artificial neural networks. LIBLICE 2004 – Progresses in organic, bioorganic and pharmaceutic chemistry, Nymburk 28. – 30. 11. 2003, Poster presentation.
3. Kassa J, Cabal J. A comparison of the efficacy of acetylcholinesterase reactivators against cyclohexyl methylphosphonofluoridate (GF agent) by in vitro and in vivo methods. Pharmacol Toxicol 1999; 84:41–5. <https://doi.org/10.1111/j.1600-0773.1999.tb02109.x>
4. Kassa J, Cabal J. A comparison of the efficacy of a new asymmetric bispyridinium oxime BI-6 with presently used oximes and H oximes against sarin by in vitro and in vivo methods. Hum Exp Toxicol 1999; 18:560–5. <https://doi.org/10.1191/096032799678845106>
5. Kassa J, Cabal J. A comparison of the efficacy of a new asymmetric bispyridinium oxime BI-6 with currently available oximes and H oximes against soman by in vitro and in vivo methods. Toxicology 1999; 132:111–8. <https://doi.org/10.1016/S0300-483X(98)00146-2>
6. Kassa J, Krejcova G. Neuroprotective Effects of Currently Used Antidotes in Tabun-Poisoned Rats. Pharmacology and Toxicology 2003; 92:258–64. <https://doi.org/10.1034/j.1600-0773.2003.920602.x>
7. Kassa J, Krejčová G, Samnaljev I. A comparison of the neuroprotective efficacy of pharmacological pretreatment and antidotal treatment in soman-poisoned rats. Acta Med (Hradec Králové) 2003; 46(3):101–7.
8. Kassa J, Kročová Z, Ševelová L, Sheshko V, Kasalová I, Neubauerová V. Low-level sarin-induced alteration of immune system reaction in inbred BALB/c mice. Toxicology 2003; 187:195–203. <https://doi.org/10.1016/S0300-483X(03)00051-9>
9. Krejcova G, Kassa J. Neuroprotective efficacy of pharmacological pretreatment and antidotal treatment in tabun-poisoned rats. Toxicology 2003; 185: 128–39.
10. Kuča K, Bielavský J, Cabal J, Bielavska M. Synthesis of a potentesis of a potentof acetylcholinesterase – 1–(4–hydroxyiminomethylpyridinium)-3–(carbamoylpyridinium)- propane dibromide. Tetrahedron Lett 2003; 44:3123–5. <https://doi.org/10.1016/S0040-4039(03)00538-0>
11. Kuča K, Bielavský J, Cabal J, Kassa J. Synthesis of a new reactivator of tabun-inhibited acetylcholinesterase. Bioorg Med Chem. Lett 2003; 13:3545–7. <https://doi.org/10.1016/S0960-894X(03)00751-0>
12. Kuča K, Cabal J, Kassa J. A comparison of the efficacy of a bispyridinium oxime – 1,4–bis-(2–hydroxyiminomethylpyridinium) butane dibromide and currently used oximes to reactivate sarin, tabun or cyclosarin-inhibited acetylcholinesterase by in vitro methods. Pharmazie 2004 In press.
13. Kuča K, Cabal J, Patočka J, Kassa J. Synthesis of bisquaternary symmetric –χ,δ- bis(2–hydroxyiminomethylpyridinium)alkane dibromides and their reactivation of cyclosarin-inhibited acetylcholinesterase. Lett Org Chem 2004; 1:84–6. <https://doi.org/10.2174/1570178043488761>
14. Kuča K, Dohnal V. 1,3–bis(2–hydroxyiminomethylpyridinium) propane as the potential reactivator of the acetylcholinesterase inhibited by nerve agents. Acta Med (Hradec Králové) 2004, In press.
15. Kuča K, Kassa J. A comparison of the ability of a new byispyridinium oxime – 1–(4–hydroxyiminomethylpyridinium)-4–(4–carbamoylpyridinium)butane dibromide and currently used oximes to reactivate nerve agent-inhibited rat brain acetylcholinesterase by in vitro methods. J Enzyme Inhib Med Chem 2003; 18: 529–35. <https://doi.org/10.1080/14756360310001605552>
16. Kuča K, Kassa J. In Vitro reactivation of acetylcholineesterase using the oxime K027. Vet Hum Toxicol 2004, 46:15–18.
17. Kuča K, Patočka J. Reactivation of cyclosarin-inhibited rat brain acetylcholinesterase by pyridinium-oximes. J. Enzime Inhib Med Chem 2004; 19:39–43. <https://doi.org/10.1080/1475636031000163850>
18. Kuča K, Patočka J, Cabal J. Reactivation of organophosphate inhibited acetylcholinesterase activity by α,ω-bis-(4-hydroxyiminomethylpyridinium)alkanes in vitro. J Appl Biomed 2003, 1:207–11.
19. Ševelová L., Vachek J. Effect of methoxime combined with anticholinergic, anticonvulsant or anti-HCN drugs in tabun-poisoned mice. Acta Medica (Hradec Králové) 2003, 46:109–12.
20. Zajtchuk R, Bellamy RF. Medical aspects of chemical and biological warfare. Office of the Surgeon General, Department of the Army, United states of America, 1997.
front cover

ISSN 1211-4286 (Print) ISSN 1805-9694 (Online)

Open access journal

Archive