Low Dose Ketoconazole Therapy and Thyroid Functions in Rats

Çaksen, Hüseyin; Tutuş, Ahmet; Kurtoğlu, Selim; Öztürk, Figen; Okumuş, Yüksel; Çoksevim, Bekir

doi:10.14712/18059694.2019.77

Acta Medica > Archive > 2002, Vol. 45 > Issue 4 > Low Dose Ketoconazole Therapy and…

Acta Med. 2002, 45: 177-179

https://doi.org/10.14712/18059694.2019.77

Low Dose Ketoconazole Therapy and Thyroid Functions in Rats

Hüseyin Çaksen^a, Ahmet Tutuş^b, Selim Kurtoğlu^c, Figen Öztürk^d, Yüksel Okumuş^d, Bekir Çoksevim^e

^aYüzüncü Yıl University, Van, Faculty of Medicine, Department of Pediatrics, Turkey
^bErciyes University, Kayseri, Faculty of Medicine, Department of Nuclear Medicine, Turkey
^cErciyes University, Kayseri, Faculty of Medicine, Department of Pediatrics, Turkey
^dErciyes University, Kayseri, Faculty of Medicine, Department of Pathology, Turkey
^eErciyes University, Kayseri, Faculty of Medicine, Department of Physiology, Turkey

Received May 1, 2002
Accepted November 1, 2002

To determine whether low dose ketoconazole (KTZ) has antithyroid action, we studied thyroid function tests in the 13 rats treated with KTZ (20 mg/kg twice daily) for thirty days. Serum triiodothyronine and thyroxine levels were decreased (P <0.05) and serum thyroid-stimulating hormone levels were mildly increased (P >0.05) at the end of treatment. Histopathological analysis of the thyroid glands demonstrated an increase in cylindrical cells in study group, but the epithelial cells were mainly cubical in control group. These findings showed that low dose KTZ had antithyroid effect in rats. The responsible mechanisms may be direct effect of the drug on thyroid gland.