Acta Med. 2002, 45: 107-110

https://doi.org/10.14712/18059694.2019.64

Effect of Atropine and the Oxime HI-6 on Low-Level Sarin-Induced Alteration of Performance of Rats in a T-Maze

Gabriela Krejčová, Jiří Kassa, Josef Vachek

Purkyně Military Medical Academy in Hradec Králové, Department of Toxicology, Hradec Králové, Czech Republic

Received April 1, 2002
Accepted May 1, 2002

References

1. Afifi AA, Azen SP. Statistical analysis and computer oriented approach. 2nd ed. New York: Academic Press, 1979:442–5.
2. Buccafusco JJ, Heithold DL, Chon SH. Long-term behavioral and learning abnormalities produced by the irreversible cholinesterase inhibitor soman: effect of a standard pretreatment regimen and clonidine. Toxicol Lett 1990; 52:319–29. <https://doi.org/10.1016/0378-4274(90)90042-K>
3. Bushnell PJ, Padilla SS, Ward T, Pope CN, Olszyk VB. Behavioral and neurochemical changes in rats dosed repeatedly with diisopropylfluorophosphate. J Pharmacol Exp Ther 1991; 256:741–50.
4. Fernando JC, Hoskins BH, Ho IK. A striatal serotonergic involment of the behavioural affects of anticholinesterase organophosphates. Eur J Pharmacol 1984; 98:129–32. <https://doi.org/10.1016/0014-2999(84)90118-3>
5. Fontana DJ, Daniels SE, Henderson C, Eglen RM, Wong EHF. Ondansetron improves cognitive performance in the Morris water maze spatial navigation task. Psychopharmacology 1995; 120(4):409–17. <https://doi.org/10.1007/BF02245812>
6. Gause EM, Hartmann RJ, Leal BZ, Geller I. Neurobehavioral effects of repeated subletal soman in primates. Pharmacol Biochem Behav 1985; 23:1003–12. <https://doi.org/10.1016/0091-3057(85)90107-8>
7. Kassa J. Comparison of efficacy of two oximes (HI-6 and obidoxime) in soman poisoning in rats. Toxicology 1995; 101:67–74. <https://doi.org/10.1016/0300-483X(95)03091-S>
8. Kassa J, Koupilová M. Neuroprotective effects of currently used antidotes in soman- poisoned rats. Pharmacol Biochem Behav 2000; 67:663–8. <https://doi.org/10.1016/S0091-3057(00)00410-X>
9. Kassa J, Koupilová M, Vachek J. Long term effects of low-level sarin inhalation exposure on the spatial memory of rats in a T-maze. Acta Med (Hradec Králové) 2001; 44(3):93–6.
10. Kok A. REM sleep pathway and anticholinesterase intoxication: a mechanism for nerve agent-induced, central respiratory failure. Med Hypotheses 1993; 41:141–9. <https://doi.org/10.1016/0306-9877(93)90061-T>
11. Koupilová M, Herink J. Effects of mescaline and its derivate N-(3,4,5-trimethoxyethyl)- aziridine on the spatial orientation of rats in T-maze. Physiol Bohem 1989; 38:497–502.
12. Koupilová M, Herink J. An attempt to antagonize DSP-4 induced impairment of the performance of rats in a T-maze. Homeostasis 1995; 36:41–2.
13. Koupilová M, Vachek J, Fusek J, Patočka J, Herink J. Neurotoxic effects of soman in animal experimental poisoning and the influence of therapy. Homeostasis 1996; 37:266.
14. Lemercier G, Carpantier P, Sentenac-Roumanou H, Morelis P. Histological and histochemical changes in the central nervous system of the rat poisoned by an irreversible anticholinesterase organophosphorus compound. Acta Neuropathol 1983; 61:123–9. <https://doi.org/10.1007/BF00697391>
15. Marrs TC. Organophosphate poisoning. Pharmacol Ther 1993; 58:51–66. <https://doi.org/10.1016/0163-7258(93)90066-M>
16. Maxwell DM, Lenz DE, Groff WA, Kaminskis A, Froehlich HL. The effect of blood flow and detoxication on in vivo cholinesterase inhibition by soman in rats. Toxicol Appl Pharmacol 1987; 88:66–76. <https://doi.org/10.1016/0041-008X(87)90270-5>
17. McDonald BE, Costa LG, Murphy SD. Spatial memory impairment and central muscarinic receptor loss following prolonged treatment with organophosphates. Toxicol Lett 1988; 40:47–56. <https://doi.org/10.1016/0378-4274(88)90182-8>
18. Mc Leod CG, Singer AW, Harrington DG. Acute neuropathology in soman poisoned rats. Neurotoxicology 1982; 297:681–3.
19. Petras JM. Soman neurotoxicity. Fundam Appl Toxicol 1981; 1:242–9. <https://doi.org/10.1016/S0272-0590(81)80065-6>
20. Rafaelle K, Olton D, Annau Z. Repeated exposure to diisopropylfluorophosphate (DFP) produces increased sensitivity to cholinergic antagonists in discrimination retention and reversal. Psychopharmacology (Berlin) 1990; 100:267–74. <https://doi.org/10.1007/BF02244417>
21. Taylor P. Anticholinesterase agents. In: Hardman JG, Limbird LE (eds): The Pharmacological Basis of Therapeutics, 9th ed. New York: McGraw Hill, 1996: 129.
22. van Helden HPM, Busker RW, Melchers BPC, Bruijnzeel PLB. Pharmacological effects of oximes: how relevant are they? Arch Toxicol 1996; 70:779–86. <https://doi.org/10.1007/s002040050340>
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