Determination of Serum B<sub>12</sub> Vitamin and Folic Acid Levels in Patient with Stroke

Yılmaz, Necat; Yılmaz, Mustafa; Pençe, Sadrettin; Özaslan, Jale; Koçoğlu, Hasan; Yılmaz, Gözen

doi:10.14712/18059694.2019.85

Acta Medica > Archive > 2001, Vol. 44 > Issue 1 > Determination of Serum B₁₂…

Acta Med. 2001, 44: 37-39

https://doi.org/10.14712/18059694.2019.85

Determination of Serum B₁₂ Vitamin and Folic Acid Levels in Patient with Stroke

Necat Yılmaz^a, Mustafa Yılmaz^b, Sadrettin Pençe^c, Jale Özaslan^a, Hasan Koçoğlu^d, Gözen Yılmaz^e

^aUniversity of Gaziantep, Faculty of Medicine, Department of Biochemistry, Turkey
^bUniversity of Gaziantep, Faculty of Medicine, Department of Neurology, Turkey
^cUniversity of Gaziantep, Faculty of Medicine, Department of Physiology, Turkey
^dUniversity of Gaziantep, Faculty of Medicine, Department of Anestesiology and Reanimation, Turkey
^eUniversity of Gaziantep, Faculty of Medicine, Tanı Radiodiagnostic Center, Turkey

Received September 1, 2000
Accepted January 1, 2001

The aim of this study is to evaluate whether any relationship between stroke and vitamin B₁₂, folic acid concentration. We examined 50 patients with stroke (male: 26 and female: 24) aged between (X±SD, year) 59±14 and 16 control subjects (male: 6 and female: 10) aged between (X±SD, year) 53±11. Patients were classified into two groups as infarct and hemorrhagic by using Computerised Brain Tomography and Cranial Nuclear Magnetic Resonance Imaging techniques. The percentage of patients with infract was 47.5 % in female and 52.5 % in male while it was 40 % in female and 60 % in male with hemorrhagic. The vitamin B₁₂ levels of patients with infarct, hemorrhagic and control group were found as X±SEM, 355±47 pg/ml, 313±58 pg/ml, 1569±258 pg/ml and folic acid levels 13.4±2.6 ng/ml, 7.7±1.0 ng/ml, 14.8±4.0 ng/ml, respectively. The significant difference was found between subgroups of patients with stroke and control group in both folic acid and B₁₂ vitamin levels (p<0.001 and p<0.0001, respectively). But, there was no significant difference between vitamin B₁₂ and folic acid levels of patients with hemorrhagic and infarct. In order to well understand the effects of these vitamin in patients with stroke, more detailed follow up studies with long period are needed.