Acta Med. 2001, 44: 29-32

https://doi.org/10.14712/18059694.2019.83

Association Between Polymorphism of the Angiotensin I Converting Enzyme Gene and Hypertension in Turkish Type II Diabetic Patients

Mustafa Araza, Sükrü Aynacioglub, Sebnem Aktarana, Belgin Alasehirlib, Vahap Okana

aGaziantep University, Medical Faculty, Department of Internal Medicine, Gaziantep, Turkey
bGaziantep University, Medical Faculty, Department of Pharmacology, Gaziantep, Turkey

Received September 1, 2000
Accepted January 1, 2001

It has been suggested that an insertion/deletion (I/D) polymorphism in intron 16 of the angiotensin converting enzyme (ACE) gene may be associated with essential hypertension. The aim of this study was to examine the association between ACE I/D polymorphism with blood pressure level and hypertension status in Turkish type 2 diabetic subjects. Hundred and seven hypertensive (78 female, 29 male) and 132 normotensive type 2 diabetic subjects (73 female, 59 male) and 138 sex and age matched control subjects (87 female, 51 male) without diabetes and hypertension were included into the study. The I/D polymorphism was determined by polymerase chain reaction (PCR). There were no statistically difference in genotypic and allelic frequencies of the ACE I/D polymorphism between the hypertensive and normotensive diabetic patients and control subjects. Also no significant differences was detected in systolic and diastolic blood pressure among three different genotypes. ACE I/D polymorphism does not seem to play an important role in the development of hypertension in Turkish type 2 diabetic subjects, but prospective studies may show an association between ACE gene polymorphism and the development of hypertension in diabetic subjects.

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