Acta Med. 2001, 44: 15-19

https://doi.org/10.14712/18059694.2019.81

The Alveolar Septal Thickness and Type II Pneumocytes Number in Irradiated Lungs, Time Expression and the Effect of Pentoxifylline

Jan Österreichera, Jaroslav Mokrýb, Leoš Navrátilc, Jiří Knížeka, Jiřina Vávrováa, Jiří Škopekc, Aleš Macelaa

aPurkyně Military Medical Academy in Hradec Králové, Department of Radiobiology and Immunology, Hradec Králové, Czech Republic
bCharles University in Prague, Faculty of Medicine in Hradec Králové, Department of Histology and Embryology, Hradec Králové, Czech Republic
cCharles University in Prague, 1st Medical Faculty, Department of Biophysics, Prague, Czech Republic

Received November 1, 2000
Accepted January 1, 2001

References

1. Denekamp J. Cell kinetics and radiation biology. Int J Radiat Biol 1986; 49:357-80.
2. Doherty GM, Jensen JC, Alexander HR, Buresh CM, Norton JA. Pentoxifylline suppression of tumor necrosis factor gene transcription. Surgery 1991; 110:192-8.
3. Fajardo LF. Pathology of radiation injury. 1st ed., New York: Masson Publishing, 1982:285.
4. Fehrenbach H, Kasper M, Tschernig T et al. Keratinocyte growth factor-induced hyperplasia of rat alveolar type II cells in vivo is resolved by differentiation into type I cells and by apoptosis. Eur Respir J 1999; 14:534-44. <https://doi.org/10.1034/j.1399-3003.1999.14c10.x>
5. Fuks Z, Alfieri A, Haimovitz-Friedman A, Seddon A, Cordon-Cardo C. Intravenous basic fibroblast growth factor protects the lung but not mediastinal organs against radiation-induced apoptosis in vivo. Cancer J Sci Am 1995; 1:62.
6. Funk JO, Ernst M, Schönharting MM, Zabel P. Pentoxifylline exerts synergistic immunomodulatory effects in combination with Dexamethasone or Cyclosporin A. Int J Immunopharmacol 1995; 17:1007-16. <https://doi.org/10.1016/0192-0561(95)00096-8>
7. Gilfillan AM, Hollingsworth M, Jones AW. The pharmacological modulation of [3H] disaturated phosphatidylcholine overflow from perfused lung slices of adult rat: a new method for the study of lung surfactant secretion. Br J Pharmacol 1983; 79:363-71. <https://doi.org/10.1111/j.1476-5381.1983.tb11008.x> <PubMed>
8. Gobran LI, Rooney S. Adenylate cyclase-coupled ATP receptor and surfactant secretion in type II pneumocytes from newborn rats. Am J Physiol 1997; 272: L187-L196.
9. Goldblum SE, Hennig B, Jay M, Yoneda K, McClain CJ. Tumor necrosis factor α-induced pulmonary vascular endothelial injury. Infect Immun 1989; 57:1218-26.
10. Gross NJ. The pathogenesis of radiation-induced lung damage. Lung 1981; 159:115-25. <https://doi.org/10.1007/BF02713907>
11. Hasleton PS. Spencer’s pathology of the lung. 5th ed., New York: McGraw-Hill, 1996:1283.
12. Hurley JV. Current views of the mechanisms of pulmonary oedema. J Pathol 1976; 125:59-79. <https://doi.org/10.1002/path.1711250202>
13. Johnston CJ, Piedboeuf B, Rubin P, Williams JP, Baggs R, Finkelstein JN. Early and persistent alterations in the expression of Interleukin-1α, Interleukin-1β and Tumor necrosis factor α mRNA levels in fibrosis-resistant and sensitive mice after thoracic irradiation. Radiat Res 1996; 145:762-7. <https://doi.org/10.2307/3579368>
14. Mándi Y, Farkas G, Ocsovsky I, Nagy Z. Inhibition of tumor necrosis factor production and ICAM - 1 expression by pentoxifylline: beneficials effects in sepsis syndrome. Res Exp Med 1995; 195:297-307. <https://doi.org/10.1007/BF02576800>
15. Koo DJ, Yoo P, Cioffi WG, Bland KI, Chaudry IH, Wang P. Mechanism of the beneficial effects of pentoxifylline during sepsis: maintenance of adrenomedullin responsiveness and downregulation of proinflammatory cytokines. J Surg Res 2000; 91:70-6. <https://doi.org/10.1006/jsre.2000.5916>
16. Noel C, Copin MC, Hazzan M et al. Immunomodulatory effect of pentoxifylline during human allograft rejection: involvement of tumor necrosis factor-alpha and adhesion molecules. Transplantation 2000; 69:1102-7. <https://doi.org/10.1097/00007890-200003270-00014>
17. Österreicher J, Vávrová J, Knížek J, Nožička J, Petýrek P. Radiation pneumonitis: The model of interstitial edema. Exp Toxicol Pathol 1999; 51:491-3. <https://doi.org/10.1016/S0940-2993(99)80122-5>
18. Österreicher J, Vávrová J, Knížek J, Nožička J, Petýrek P. Radiation Pneumonitis: The Influence of Pentoxifylline and Dexamethasone on the Alveolar Septal Thickness and the Amount of Neutrophil Granulocytes. Voj Zdrav Listy–Supplementum 1999; 68:36-40.
19. Peterson TC, Neumeister M. Effect of pentoxifylline in rat and swine models of hepatic fibrosis: role of fibroproliferation in its mechanism. Immunopharmacology 1996; 31:183-93. <https://doi.org/10.1016/0162-3109(95)00048-8>
20. Rubin P, Johnston CJ, Williams JP, McDonald S, Finkelstein JN. A perpetual cascade of cytokines postirradiation leads to pulmonary fibrosis. Int J Radiat Oncol Biol Phys 1995; 33:99-109. <https://doi.org/10.1016/0360-3016(95)00095-G>
21. Silva JC, Rocha MF, Lima AA, Brito GA, de Menezes DB, Rao VS. Effects of pentoxifylline and nabumetone on the serum levels of IL-1beta and TNFalpha in rats with adjuvant arthritis. Inflamm Res 2000; 49:14-19. <https://doi.org/10.1007/PL00000198>
22. Travis EL. The sequence of histological changes in mouse lungs after single doses of X-rays. Int J Radiat Oncol Biol Phys 1980; 16:345-7. <https://doi.org/10.1016/0360-3016(80)90145-5>
23. Travis EL, Tucker SL. The relationship between functional assays of radiation response in the lung and target cell depletion. Br J Cancer 1986; 53:304-19.
24. Ulich TR, Yi ES, Longmuir K et al. Keratinocyte growth factor is a growth factor for type II pneumocytes in vivo. J Clin Invest 1994; 93:1298-1306. <https://doi.org/10.1172/JCI117086> <PubMed>
25. Vojtesek B, Staskova Z, Nenutil R et al. Monoclonal antibodies recognizing different epitopes of cytokeratin No.18. Folia Biol (Praha) 1989; 35:373-82.
26. Ward HE, Kemsley L, Davies L, Holecek M, Berend N. The pulmonary response to sublethal thoracic irradiation in the rat. Radiat Res 1993; 136:15-21. <https://doi.org/10.2307/3578634>
27. Ward WF, Kim YT, Molteni A, Ts’ao C, Hinz JM. Pentoxifylline does not spare acute radiation reactions in rat lung and skin. Radiat Res 1992; 129:107-11. <https://doi.org/10.2307/3577910>
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