Acta Med. 2000, 43: 119-124
Natural Polyamines and Their Biological Consequence in Mammals
The polyamines (putrescine, cadaverine, agmatine, spermidine and spermine), wide-spread in all organisms, have been shown to play a role in regulation of growth and differentiation of virtually all types of cells. Their role in many physiological and pathophysiological processes have been studied very intensively during the last two decades. Inhibitors of polyamine biosynthesis have potential clinical uses as antitumor and antiparasitic agents. The brief summary with regard to their biological consequences in mammals is discussed in this paper.
Keywords
Polyamine, Agmatine, Putrescine, Spermidine, Spermine, Ornithine dacarboxylase.
References
Copyright
Published by the Karolinum Press. For permission to use please write to actamedica@lfhk.cuni.cz.
