Acta Med. 2000, 43: 9-13
3-Nitropropionic Acid and Similar Nitrotoxins
3-Nitropropionic acid as well as 3-nitro-1-propanol and its β-D-glucopyranoside (miserotoxin) are the plant and fungal toxins reported to interrupt mitochondrial electron transport resulting in cellular energy deficit. These nitrotoxins induce neurological degeneration in ruminants and humans. 3-Nitropropionic acid-intoxicated rats serve as the animal model for Huntington’s disease.
Keywords
Plant toxin, Fungal toxin, Nitrotoxin, 3-nitropropionic acid, Miserotoxin, Milkvetch.
Funding
This study was supported by the grant of Ministry of Defense, project CEP MO 6602129911.
References
Copyright
Published by the Karolinum Press. For permission to use please write to actamedica@lfhk.cuni.cz.
