Acta Med. 2000, 43: 9-13

3-Nitropropionic Acid and Similar Nitrotoxins

Jiří Patočka, Jiří Bielavský, Jiří Cabal, Josef Fusek

Purkyně Military Medical Academy, Hradec Králové, Department of Toxicology, Hradec Králové, Czech Republic

Received December 1, 1999
Accepted March 1, 2000

3-Nitropropionic acid as well as 3-nitro-1-propanol and its β-D-glucopyranoside (miserotoxin) are the plant and fungal toxins reported to interrupt mitochondrial electron transport resulting in cellular energy deficit. These nitrotoxins induce neurological degeneration in ruminants and humans. 3-Nitropropionic acid-intoxicated rats serve as the animal model for Huntington’s disease.


This study was supported by the grant of Ministry of Defense, project CEP MO 6602129911.


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