Acta Med. 1999, 42: 93-96
https://doi.org/10.14712/18059694.2019.150
Is Factor V Leiden a Risk Factor for Fetal Loss?
References
1. A, Verdy E, Heim A et al. Does the Q506 mutation of factor V contribute to fetal loss or stillbirth? Thromb Haemost 1997; Suppl. 1:759-60.
2. RM, Koeleman BPC, Koster T et al. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 1994; 369:64-7.
<https://doi.org/10.1038/369064a0>
3. B. Inherited thrombophilia and pregnancy loss. Thromb Haemost 1999; 82:634-40.
4. B, Mandel H, Lanir A et al. Activated protein C resistance can be associated with recurrent fetal loss. Br J Haematol 1997; 97:55l-4.
<https://doi.org/10.1046/j.1365-2141.1997.882901.x>
5. B, Sarig G, Weiner Z, Younis J, Blumenfeld Z, Lanir N. Thrombophilic polymorphism in women with fetal loss. Blood 1998; 92(Suppl. 1):558a.
6. J, Horellou MH, VanDreden P, Lecompte T, Samama M. Thrombosis and pregnancy in congenital deficiencies in AT III, protein C or protein S. Thromb Haemost 1990; 63:319-20.
7. B. Resistance to activated protein C, the Arg506 to Gln mutation in the factor V gene, and venous thrombosis. Thromb Haemost 1995; 73:739-42.
8. B. Inherited thrombophilia: resistance to activated protein C as a pathogenic factor of venous thromboembolism. Blood 1995; 85:607-14.
9. B, Carlsson M, Svensson PJ. Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C; prediction of a cofactor to activated protein C. Proc Natl Acad Sci U.S.A 1993; 90:1004-8.
<https://doi.org/10.1073/pnas.90.3.1004>
<PubMed>
10. AL, Atrash HK, Lawson HW, Colberg KS. Obstetrical pulmonary embolism mortality. United States 1970-85. Am J Public Health 1990; 80:720-2.
<https://doi.org/10.2105/AJPH.80.6.720>
11. E, Margaglione M, Colaizzo D et al. Factor V Leiden is associated with repeated and recurrent unexplained fetal losses. Thromb Haemost 1997; 77:822-4.
12. D, Maliekel K, Sushko E et al. Activated protein C resistance in cancer patients. Thromb Haemost 1997; Suppl.1:316.
13. M, Tengborn L, Abildgaard U. Pregnancy in women with congenital antithrombin III deficiency: Experience of treatment with heparin and antithrombin. Gynecol Obstet Invest 1982; 14:127-41.
<https://doi.org/10.1159/000299460>
14. A, Dahlbäck B. Activated protein C resistance. Vessels 1997; 3:3-10.
15. Högberg U. Maternal mortality in Sweden. Thesis,Umea,Sweden 1985;118.
16. U, Andersson NE, Rosen S, Tengborn L, Hellgren M. APC resistance and other haemostatic variables during pregnancy and puerperium. Thromb Haemost 1999; 81:527-31.
17. J, Saxena R, Mohanty S et al. APC resistance in recurrent fetal loss in the Indian population. Br J Haematol 1998; 103:588.
<https://doi.org/10.1046/j.1365-2141.1998.01091.x>
18. PG, Svensson PJ, Maršál K, Grenner L, Luterkort M, Dahlbäck B. Activated protein C resistance (f V Q506) and pregnancy. Thromb Haemost 1999; 81:532-7.
19. JR, Henkens CMA, Heringa et al. Acquired APC resistance related to oral contraceptives and pregnancy and its possible implications for clinical practise. Blood Coag Fibrinol 1997; 8:152-4.
<https://doi.org/10.1097/00001721-199703000-00011>
20. O, Friso S, Manzato F et al. Resistance to activated protein C in healthy women taking oral contraceptives. Br J Haematol 1995; 91:465-70.
<https://doi.org/10.1111/j.1365-2141.1995.tb05323.x>
21. FE, Rosendaal FR, Walker ID et al. Increased fetal loss in women with heritable thrombophilia. Lancet 1996; 348:913-16.
<https://doi.org/10.1016/S0140-6736(96)04125-6>
22. PM, Miletich JP, Buring JE et al. Factor V Leiden mutation as a risk factor for recurrent pregnancy loss. Ann Intern Med 1998; 28:1000-3.
<https://doi.org/10.7326/0003-4819-128-12_Part_1-199806150-00007>
23. BJ, Friedrich PW, Simioni P et al. The risk of abortion and stillbirth in antithrombin-protein C and protein S deficient women. Thromb Haemost 1996; 75:387-8.
24. GM. Recurrent miscarriage I: definition and epidemiology. Lancet 1990; 336:673-5.
<https://doi.org/10.1016/0140-6736(90)92159-F>
25. PJ, Dahlbäck. Resistance to activated protein C as a basis for venous thrombosis. N Engl J Med 1994; 330:517-22.
<https://doi.org/10.1056/NEJM199402243300801>


