Acta Med. 1999, 42: 89-92

https://doi.org/10.14712/18059694.2019.149

The Influence of Dimethoxybenfluron on Biochemical and Haematological Parameters in Rabbits

Jarmila Macháčkováa, Vladimír Geršla, Radomír Hrdinab, Milan Nobilisc, Vladimír Paličkad

aCharles University in Prague, Faculty of Medicine in Hradec Králové, Department of Pharmacology, Hradec Králové, Czech Republic
bCharles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Pharmacology and Toxicology, Hradec Králové, Czech Republic
cInstitute of Experimental Biopharmaceutics, Czech Academy of Sciences in Hradec Králové, Czech Republic
dUniversity Teaching Hospital in Hradec Králové, Department of Clinical Biochemistry, Hradec Králové, Czech Republic

Received April 1, 1999
Accepted September 1, 1999

The influence of repeated i.v. administration of dimethoxybenfluron (NO-1-B) (12 or 24 mg base/kg once weekly, 10 weeks) on biochemical and haematological parameters were studied in rabbits in vivo. No significant changes were mostly found in the serum ion levels between the dimethoxybenfluron and the control groups, as well as in most of other biochemical parameters (including total protein and albumin levels). Nevertheless, the lower dose of dimethoxybenfluron caused an increase in the glucose level. Furthermore, no significant changes were mostly present also in haematological parameters in the dimethoxybenfluron groups of rabbits (a mild decrease in thrombocytes and leucocytes). The results of our study support an assumption of good tolerance of dimethoxybenfluron from the viewpoint of its influence on biochemical and haematological parameters in rabbits and may be considered of importance for a possible therapeutic use of the derivatives.

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