Acta Med. 1999, 42: 69-72
Influencing of Spatial Memory in Rats by DSP-4 and Mescaline
Behavioural effects of two experimental neurotoxins, mescaline and DSP-4 (N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine), on retention of spatial orientation were studied in the T - maze. The stereotaxic administration of both neurotoxins into the selected brain structures was chosen to reveal this effect. The intensity and time course of the neurotoxic effect were dependent on the brain area administered. Nevertheless, the lengthening of the latencies in reaching the goal was generally more marked after mescaline in comparison with DSP-4.
Keywords
DSP-4, Learning, Mescaline, Stereotaxic administration, T - maze.
Funding
This work was partly supported by grant No. 307/95/1537 from the Grant Agency of the Czech Republic.
References
Copyright
Published by the Karolinum Press. For permission to use please write to actamedica@lfhk.cuni.cz.
