Acta Med. 1998, 41: 155-157
https://doi.org/10.14712/18059694.2019.181
Huperzine A - An Interesting Anticholinesterase Compound from the Chinese Herbal Medicine
References
1. Y, Peginns JO, Doctor BP. Mechanism of inhibition of cholinesterases by huperzine A. Biochem Biophys Res Commun 1992; 184:719-26.
<https://doi.org/10.1016/0006-291X(92)90649-6>
2. DH, Ren H, Tang XC. Huperzine A, a novel promising acetylcholinesterase inhibitor. Neuroreport 1996; 20:97-101.
<https://doi.org/10.1097/00001756-199612200-00020>
3. SJ, Tuckmantel W, Kozikowski AP. Huperzine A - a potent acetylcholinesterase inhibitor of use in the treatment of Alzheimer's disease. Acta Crystallogr C 1991; 47:824-7.
<https://doi.org/10.1107/S0108270190008952>
4. J, Raveh L, Doctor BP, Ashani Y. Huperzine A as a pretreatment candidate drug against nerve agent toxicity. Life Sci 1994; 54:991-7.
<https://doi.org/10.1016/0024-3205(94)00501-X>
5. LC, Chen SS, Lu WH, Tang XC. Effects of huperzine A on electroencephalography power spectrum in rabbits. Chung Kuo Yao Li Hsueh Pao 1989; 10:496-500.
6. I, Tang XC, Kindel GL, Kozikowski AP. Natural and synthetic huperzine A: effect on cholinergic function in vitro and in vivo. Ann N Y Acad Sci 1993; 695:304-6.
<https://doi.org/10.1111/j.1749-6632.1993.tb23071.x>
7. AP, Miller CP, Yamada F et al. Delineating the pharmacophoric elements of huperzine A: importance of the unsaturated three-carbon bridge to its AChE inhibitory activity. J Med Chem 1991; 34:3399-402.
<https://doi.org/10.1021/jm00116a010>
8. S, Corey J, Tang XC, Wulfert E, Hanin I. Acute and chronic studies with the anticholinesterase huperzine A: effect on central nervous system cholinergic parametters. Neuropharmacology 1991; 30:763-8.
<https://doi.org/10.1016/0028-3908(91)90184-D>
9. M, Miller JH, Yamada F, Tuckmantel W, Kozikowski AP. Potencies and stereoselectivities of enantiomers of huperzine A for inhibition of rat cortical acetylcholinesterase. Eur J Pharmacol 1991; 203:303-5.
<https://doi.org/10.1016/0014-2999(91)90730-E>
10. YP, Kozikowski AP. Prediction of the binding site of huperzine A in actylcholin-esterase by docking studies. J Comput Aided Mol Des 1994; 8:669-81.
<https://doi.org/10.1007/BF00124014>
11. BC, Wang M, Zhou ZF, Chen K, Zhou RR, Chen GS. Pharmacokinetics of tablet huperzine A in six volunteers. Chung Kuo Uao Li Hsueh Pao 1995; 16:396-8.
12. ML, Harel M, Pang YP, Silman I, Kozikowski AP, Sussman JL. Structure of acetylcholinesterase complexed with the nootropic alkaloid, (-)-huperzine A. Nat Struct Biol 1997; 1:57-63.
<https://doi.org/10.1038/nsb0197-57>
13. A, Qian N, Kovach IM et al. Identification of amino acid residues involved in the binding of huperzine A to cholinesterases. Protein Sci 1994; 3:1770-8.
<https://doi.org/10.1002/pro.5560031017>
<PubMed>
14. AA. Traditional Chinese herbal medicine looks promissing. JAMA 1997; 277:776.
<https://doi.org/10.1001/jama.1997.03540340010004>
15. XC, De Sarno P, Sugaya K, Giacobini E. Effect of huperzine A, a new cholinesterase inhibitor, on the central cholinergic system of the rat. J Neurosci Res 1989; 24:276-85.
<https://doi.org/10.1002/jnr.490240220>
16. XC, Kindel GH, Kozikowski AP, Hanin I. Comparison of the effect of natural and synthetic huperzine A on rat brain cholinergic function in vitro and in vivo. J Ethnopharmacol 1994; 44:147-55.
17. SS, Gao ZX, Weng Z et al. Efficacy of tablet huperzine-A on memory, cognition, and behavior in Alzheimer's disease. Chung Kuo Yao Li Hsueh Pao 1995; 16:391-5.
18. QX, Yi FH, Xi CT. Huperzine A ameliorates the spatial working memory impairments induced by AF64A. Neuroreport 1995; 13:2221-4.
19. QX, Yi FH, Xi CT. Huperzine A - a novel promising acetylcholinesterase inhibitor. Neuroreport 1996; 8:97-101.
