Acta Med. 1998, 41: 125-130

Muscle GLUT-4 and Insulin Binding to Erythrocytes and to Adipose, Liver and Muscle Tissue in Genetically Hypertensive Obese Rats and in Their Lean Siblings: Effect of Long Lasting Terguride Treatment

Věroslav Goldaa, Jiřina Hilgertováb, Štefan Zóradc

aInstitute of Experimental Neurosurgery, Charles University, Faculty of Medicine and Teaching Hospital, Hradec Králové, Czech Republic
bLaboratory for Endocrinology and Metabolism, Charles University, Faculty of Medicine, Prague, Czech Republic
cInstitute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovak Republic

Received May 1, 1998
Accepted June 1, 1998

Experiments were performed in the genetically hypertensive obese rats of Koletsky type (SHR/N-cp) and in their lean siblings of both sexes.Insulin binding to erythrocytes and to adipose tissue, lever tissue and muscle tissue was monitored in the control animals and in the animals under the long lasting terguride treatment. In control animals insulin binding shows substrain and tissue dependence being elevated in lean rats except insulin binding to erythrocytes where inverse is true. Terguride increases percentage of specific insulin binding to erythrocytes in all groups except obese females, terguride increases percentage of specific binding to adipose tissue except lean females, the mentioned drug remained without effect in muscle tissue in all group except lean females where drug induced elevation was detected. The effect of terguride in liver tissue was monitored only in males of both substrains, elevation was found only in lean. GLUT-4 was analyzed only in muscle tissue. The effect of terguride was found in obese females, i.e., in the group which shows reduced GLUT-4 relative to lean females.


This paper was supported by Internal Grant Agency of Ministry of Health of the Czech Republic No 3684-3.


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