Acta Med. 1998, 41: 87-90

https://doi.org/10.14712/18059694.2019.170

Hypocholesterolemic Effect of Pravastatin is Associated with Increased Content of Antioxidant Vitamin-E in Cholesterol Fractions

Vladimír Bláha, Zdeněk Zadák, Dagmar Solichová, Miluše Brátová, Eduard Havel

Department of Metabolic Care and Gerontology, Charles University, Faculty of Medicine and Teaching Hospital, Hradec Králové, Czech Republic

Received January 1, 1998
Accepted May 1, 1998

References

1. Aaran RK, Nikkari T. HPLC method for the simultaneous determination of beta-carotene, retinol and alpha-tocopherol in serum. J Pharmacol Biomed Analysis 1988; 7:853-7. <https://doi.org/10.1016/0731-7085(88)80101-8>
2. Abbey M, Nestel PJ, Baghurst PA. Antioxidant vitamins and low density lipoprotein oxidation. Am J Clin Nutr 1993; 58:255. <https://doi.org/10.1093/ajcn/58.4.525>
3. Allain CC, Poon LC, Chan CSG, Richmond W, Fu PC. Enzymatic determination of total serum cholesterol. Clin Chem 1974; 20:470. <https://doi.org/10.1093/clinchem/20.4.470>
4. Bucolo G, David H. Quantitative determination of serum triglycerides by the use of enzymes. Clin Chem 1973; 19:476. <https://doi.org/10.1093/clinchem/19.5.476>
5. De Leenheer AP, De Bevere VORC, De Ruyter MGM, Clayes AE. Simultaneous determination of retinol and (-tocopherol in human serum by HPLC. J Chromatogr 1979; 162:402-13. <https://doi.org/10.1016/S0378-4347(00)81528-5>
6. Dieber-Rotheneder M, Puhl H, Waeg G et al. Effect of oral supplementation with D-alpha-tocopherol on the vitamin E content of human low density lipoproteins and resistance to oxidation. J Lipid Res 1991; 32:1325-32.
7. Esterbauer H, Rotheneder M, Striegl G et al. Vitamin E and other lipophilic antioxidants protect LDL against oxidation. Fat Sci Technol 1989; 91:316.
8. Esterbauer H, Dieber-Rotheneder M, Waeg G, Striegl G, Jurgens G. Biochemical, structural and functional properties of oxidized low-density lipoprotein. Chem Res Toxicol 1990; 3:77-92. <https://doi.org/10.1021/tx00014a001>
9. Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults. Summary of the second report of the National Cholesterol Education Program (NCEP) Expert Panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel II). JAMA 1993; 269:3015-23.
10. Franceschini G, Cassinotti M, Vecchio G et al. Pravastatin effectively lowers LDL cholesterol in familial combined hyperlipidemia without changing LDL subclass pattern. Arterioscler Thromb 1994; 14:1569-75. <https://doi.org/10.1161/01.ATV.14.10.1569>
11. Gaw A, Packard CJ, Murray EF et al. Effects of simvastatin on apoB metabolism and LDL subfraction distribution. Arterioscler Thromb 1993; 13:170-89. <https://doi.org/10.1161/01.ATV.13.2.170>
12. Goldstein JL, Brown MS. The low-density lipoprotein pathway and its relation to atherosclerosis. Ann Rev Biochem 1977; 46:897. <https://doi.org/10.1146/annurev.bi.46.070177.004341>
13. Hoffman R, Brooks GJ, Aviram M. Hypolipidemic drugs reduce lipoprotein susceptibility to undergo lipid peroxidation: in vitro and ex vivo studies. Atherosclerosis 1992; 93:105-13. <https://doi.org/10.1016/0021-9150(92)90204-T>
14. Kayden HJ, Traber MG. Absorption, lipoprotein transport, and regulation of plasma concentrations of vitamin E in humans. J Lipid Res 1993; 34:343-58.
15. Maes M, Weeckx S, Wauters A et al. Biological variability in serum vitamin E concentrations: relations to serum lipids. Clin Chem 1996; 42:1824-31. <https://doi.org/10.1093/clinchem/42.11.1824>
16. Miller NJ, Paganga G, Wiseman S et al. Total antioxidant activity of low density lipoproteins and the relationship with (-tocopherol status. FEBS Lett 1995; 365:164-6. <https://doi.org/10.1016/0014-5793(95)00448-I>
17. Mitchinson MJ, Ball RY, Carpenter KH, Enright JH, Brabbs CE. Ceroid, macrophages and atherosclerosis. Biochem Soc Transact 1990; 18:1066-9. <https://doi.org/10.1042/bst0181066>
18. Naito HK. Lipoprotein separations using the TL-100 tabletop ultracentrifuge. Application Note Beckman DS-693.
19. Palinsky W, Rosenfeld ME, Herttuala SY et al. Lowdensity lipoprotein undergoes oxidative modification in vivo. Proc Natl Acad Sci 1989; 86:1372-6. <https://doi.org/10.1073/pnas.86.4.1372> <PubMed>
20. Shepherd J. Fibrates and statins in the treatment of hyperlipidemia: in appraisal of their efficacy and safety. Eur Heart J 1995; 16:5-13. <https://doi.org/10.1093/eurheartj/16.1.5>
21. Steinberg D, Parthasarathy S, Carew TE, Khoo JC, Witztum JL. Beyond cholesterol: Modifications of low density lipoprotein that increase its atherogenecity. N Engl J Med 1989; 320:915. <https://doi.org/10.1056/NEJM198901053200122>
22. Stocker R, Bowry VW, Frei B. Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherol. Proc Natl Acad Sci USA 1991; 88:1646. <https://doi.org/10.1073/pnas.88.5.1646> <PubMed>
23. Ziouzenkova O, Winklhofer-Roob BM, Puhl H, Roob JM, Esterbauer H. Lack of correlation between (-tocopherol content of plasma and LDL, but high correlations for (- tocopherol and caroteinoids. J Lipid Res 1996; 37:1936-46.
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