Acta Med. 1998, 41: 3-11

https://doi.org/10.14712/18059694.2019.160

Ventromedial Nucleus of Hypothalamus is Related to the Development of Cancer-Induced Anorexia: In Vivo Microdialysis Study

Vladimír Bláhaa, Zhong-jin Yangb, Michael M. Meguidb, Jia-ke Chaib, Albert Olerb, Zdeněk Zadáka

aDepartment of Metabolic Care and Gerontology, Charles University, Faculty of Medicine and Teaching Hospital, Hradec Králové, Czech Republic
bNeuroscience Program, Surgical Metabolism and Nutrition Laboratory, Departments of Surgery and Pathology, University Hospital, SUNY Health Science Center, 750 E. Adams Street, Syracuse, NY 132101, USA

Received December 1, 1997
Accepted January 1, 1998

References

1. Blaha V, Yang Z-J, Meguid MM, Laviano A, Zadak Z, Rossi Fanelli F. Cancer anorexia is modulated by interaction of hypothalamic-VMN dopamine (DA) & serotonin (5- HT) & and not solely 5-HT as currently thought. Surg Forum 1996; 47:517-20.
2. Blundell JE. Serotonin and appetite. Neuropharmacol 1984; 23:1537-52. <https://doi.org/10.1016/0028-3908(84)90098-4>
3. Heilig M, Vecsei L, Wahlestedt C, Alling C, Widerlov E. Effects of centrally administered neuropeptide Y (NPY) and NPY13-36 on the brain monoaminergic systems of the rat. J Neural Transm 1990; 79:193-208. <https://doi.org/10.1007/BF01245130>
4. Hoebel BG, Hernandez L, Schwartz DH, Mark GP, Hynter GA. Microdialysis studies of brain norepinephrine, serotonin, and dopamine release during ingestive behavior: Theoretical and clinical implications. Ann NY Acad Sci 1989; 575:171-93. <https://doi.org/10.1111/j.1749-6632.1989.tb53242.x>
5. Chance WT, von Meyenfeldt MF, Fischer JE. Changes in brain amines associated with cancer anorexia. Neurosci. Biobehav Rev 1983; 7:471. <https://doi.org/10.1016/0149-7634(83)90025-8>
6. Chance WT, von Meyenfeldt MF, Fischer JE. Serotonin depletion by 5,7-dihydroxytryptamine or para-chloroamphetamine does not affect cancer anorexia. Pharmacol Biochem Behav 1983; 18:115. <https://doi.org/10.1016/0091-3057(83)90260-5>
7. Chance WT, Cao L, Nelson JL, Foley-Nelson T, Fischer JE. Reversal of neurochemical aberrations after tumor resection. Am J Surg 1988; 155:124-30. <https://doi.org/10.1016/S0002-9610(88)80269-1>
8. Chance WT, Zhang FS, Foley-Nelson T, Fischer JE. Hyperammonemia and anorexia in Morris Hepatoma-bearing rats. Physiol Behav 1991; 50:397-401. <https://doi.org/10.1016/0031-9384(91)90085-3>
9. Chance WT, Cao L, Fischer JE. Tumor-induced alterations in brain neurotransmitter and plasma ammonia concentrations are normalized twenty-four hours after tumor resection. Life Sci 1991; 48:425-32. <https://doi.org/10.1016/0024-3205(91)90498-Z>
10. Chance WT, Balasubramaniam A, Dayal R, Brown J, Fischer J E. Hypothalamic concentration and release of neuropeptide Y into microdialysates is reduced in anorectic tumor-bearing rats. Life Sci 1994; 54:1869-74. <https://doi.org/10.1016/0024-3205(94)90144-9>
11. Chance WT, Balasubramaniam A, Fischer JE. Neuropeptide Y and the development of cancer anorexia. Ann Surg 1995; 221:579-89. <https://doi.org/10.1097/00000658-199505000-00016> <PubMed>
12. Kurzer M, Janiszewski FJ, Meguid MM. Amino acid profiles in tumor-bearing and pair-fed non tumor-bearing malnourished rats. Cancer 1988; 62:1492-6. <https://doi.org/10.1002/1097-0142(19881015)62:8<1492::AID-CNCR2820620808>3.0.CO;2-U>
13. Laviano A, Meguid MM, Renvyle T, Opara EI, Yang Z.-J, Rossi Fanelli F. Il-1a acts directly on hypothalamic VMH to mediate cancer anorexia. Surg Forum 1995; 46:491-3.
14. Leibowitz SF, Rossakis C. Pharmacological characterization of perifornical hypothalamic dopamine receptors mediating feeding inhibition in the rat. Brain Res 1979; 172:115-30. <https://doi.org/10.1016/0006-8993(79)90899-0>
15. Leibowitz SF. Neurochemical systems of the hypothalamus. Control of feeding and drinking behaviour and waterelectrolyte excretion. In: Morgane PJ, Panksepp J, eds. Handbook of the hypothalamus. New York: Marcel Dekker, 1980:299-437.
16. Leibowitz SF. Brain monoamines and peptides: role in the control of eating behavior. Federatio Proc 1986; 45:1396-1403.
17. Madden RE, Burk D. Production of viable single cell suspension from solid tumors. J Natl Cancer Inst 1961; 27:841-61.
18. McCarthy HD, McKibbin PE, Perkins AV, Linton EA, Williams G. Alterations in hypothalamic NPY and CRF in anorexic tumor-bearing rats. Am J Physiol 1993; 264:E638-E643.
19. Meguid MM, Yang Z-J, Koseki M. Eating-induced rise in LHA-dopamine correlates with meal size in normal and bulbectomized rats. Brain Res Bull 1995; 36:487-90. <https://doi.org/10.1016/0361-9230(95)92128-3>
20. Meguid MM, Yang Z-J, Gleason JR. The gut-brain brain- gut axis in anorexia: toward an understanding of food intake regulation. Nutrition 1996; 12:S57-S62. <https://doi.org/10.1016/0899-9007(95)00083-6>
21. Meguid MM, Yang Z-J, Laviano A. Meal size and meal number: relationship to dopamine levels in the ventromedial hypothalamic nucleus. Submitted to Am J Physiol, 1996.
22. Mohankumar PS, Thyagarajan S, Quadri SK. Interleukin-1b increases 5-hydroxyindolacetic acid release in the hypothalamus in vivo. Brain Res Bull 1993; 31:745-8. <https://doi.org/10.1016/0361-9230(93)90151-Z>
23. Morrison SD. Contribution of reduced hunger and premature satiety to cancerous hypophagia in rats. Cancer Res 1984; 44:1041-3.
24. Muscaritoli M, Meguid MM, Beverly JL, Yang Z-J, Cangiano C, Rossi-Fanelli F. Mechanism of early tumor anorexia. J Surg Res 1996; 60:389-97. <https://doi.org/10.1006/jsre.1996.0064>
25. Nelson KA, Walsh D, Sheehan FA. The cancer anorexia- cachexia syndrome. J Clin Oncol 1994; 12:213-25. <https://doi.org/10.1200/JCO.1994.12.1.213>
26. Norton JA, Moley JF, Green MV, Carson RE, Morrison SD. Parabiotic transfer of cancer anorexia/cachexia in male rats. Cancer Res 1985; 45:5547-9.
27. Opara EI, Laviano A, Meguid MM. Correlation between food intake and CSC IL-1a in anorectic tumor bearing rats. NeuroReport 1996; 6:750. <https://doi.org/10.1097/00001756-199503270-00011>
28. Orosco M, Nicolaidis S. Spontaneous feeding-related monoaminergic changes in the rostromedial hypothalamus revealed by microdialysis. Physiol Behavior 1992; 52:10154-1019. <https://doi.org/10.1016/0031-9384(92)90384-E>
29. Orosco M, Nicolaidis S. Insulin and glucose-induced changes in feeding and medial hypothalamic monaomines revealed by microdialysis in rats. Brain Res Bull 1994; 33:289-97. <https://doi.org/10.1016/0361-9230(94)90196-1>
30. Orosco M, Moret C, Briley M, Nicolaidis S. Effect of Mefenorex on 5-HT release: studies in vitro on rat hypothalamic slices and in vivo by microdialysis. Pharmacol Biochem Behav 1995; 50:485-90. <https://doi.org/10.1016/0091-3057(94)00323-8>
31. Parada MA, Hernandez L, Puig De Parada M, Paez X, Hoebel BG. Dopamine in the lateral hypothalamus may be nvolved in the inhibiton of locomotion related to food and water seeking. Brain Res Bull 1990; 25:961. <https://doi.org/10.1016/0361-9230(90)90195-6>
32. Pellegrino LJ, Pellegrino AS, Cushman AJ. A stereotaxic atlas of the rat brain. 2nd ed. New York: Plenum Press, 1986.
33. Samanin R, Mennini T, Garattini S. Evidence that it is possible to cause anorexia by increasing release and/or directly stimulating postsynaptic serotonin receptors in the brain. Prog Neuropsychopharmacol 1980; 4:363-9. <https://doi.org/10.1016/0364-7722(80)90006-5>
34. Shintani F, Nakaki T, Kanba S et al. Interleukin-1b augments release of norepinephrine, dopamine, and serotonin in the rat hypothalamus. J Neurosci 1993; 13:3574-81. <https://doi.org/10.1523/JNEUROSCI.13-08-03574.1993> <PubMed>
35. Schwartz DH, Hernandez L, Hoebel BG. Serotonin release in lateral and medial hypothalamus during feeding and its anticipation. Brain Res Bull 1990; 25:797-802. <https://doi.org/10.1016/0361-9230(90)90173-W>
36. Stanley BG, Leibowitz SF. Neuropeptide Y injected into the paraventricular hypothalamus: a powerful stimulant of feeding behavior. Proc Natl Acad Sci USA 1985; 82:3940. <https://doi.org/10.1073/pnas.82.11.3940> <PubMed>
37. Von Meyenfeldt M, Chance WT, Fischer JE. Correlation of changes in brain indoleamine metabolism with onset of anorexia in rats. Am J Surg 1982; 143:133. <https://doi.org/10.1016/0002-9610(82)90143-X>
38. Yang Z-J, Meguid MM. Continuous systemic interleukin- 1a infusion suppresses food intake without increasing lateral hypothalamic dopamine activity. Brain Res Bull 1995; 36:417-20. <https://doi.org/10.1016/0361-9230(94)00212-J>
39. Yang Z-J, Koseki M, Meguid MM. Laviano A. Eatingrelated increase of dopamine concentration in the LHA associated with oronasal stimulation. Am J Physiol 1996; 270:R315-R318.
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