Acta Med. 1997, 40: 95-97

https://doi.org/10.14712/18059694.2020.52

The Effects of Subchronical Exposure to SO2 on Biochemical and Hematological Parameters in Guinea Pigs

Jana Suchánkováa, Peter Višňovskýa, Vladimír Geršlb, Zdeněk Fialac, Yvona Mazurovád, Vladimír Paličkae, Jaroslava Vávrováe, Jaroslava Voglováf

aDepartment of Pharmacology a Toxicology, Charles University, Faculty of Pharmacy, Hradec Králové, Czech Republic
bDepartment of Pharmacology, Charles University, Faculty of Medicine, Hradec Králové, Czech Republic
cDepartment of Hygiene and Preventive Medicine, Charles University, Faculty of Medicine, Hradec Králové, Czech Republic
dDepartment of Histology and Embryology, Charles University, Faculty of Medicine, Hradec Králové, Czech Republic
eDepartment of Clinical Biochemistry and Diagnostics, University Teaching Hospital, Hradec Králové, Czech Republic
fDepartment of Clinical Hematology, University Teaching Hospital, Hradec Králové, Czech Republic

Received October 1, 1997
Accepted November 1, 1997

The effects of subchronical exposure to SO2 (400 ppm, 3 hours daily, 28 days) on biochemical and hematological parameters were investigated in guinea pigs. Mostly no significant changes in the values of biochemical parameters and no significant changes in hematological parameters were found. The levels of investigated ions (K+, Na+, Cl-, Ca++, Mg++ and phosphates), proteins (albumines, globulines, total proteins), enzymes (LD, ALT, AST, CK) and other biochemical parameters (urea, creatinine, bilirubin) were not significantly different between groups, with the exception of a significantly higher ALP concentration in the exposed group as compared with controls (2.17 mkat and 1.85 mkat, respectively). It can be concluded that a subchronical exposure to sulphur dioxide mostly did not induce any definite changes in biochemical and hematological parameters in guinea pigs.

Funding

This study was supported by means of Internal Grant of the Charles University No. 515/95.

References

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