Long-Term Results in Hairy Cell Leukemia Treated with 2-Chlorodeoxyadenosine

Chrobák, Ladislav; Žák, Pavel; Podzimek, Karel; Plíšková, Lenka; Foglová, Jaroslava; Maisnar, Vladimír; Dulíček, Petr; Dědič, Karel

doi:10.14712/18059694.2020.42

Acta Medica > Archive > 1997, Vol. 40 > Issue 2 > Long-Term Results in Hairy Cell Leukemia…

Acta Med. 1997, 40: 41-45

https://doi.org/10.14712/18059694.2020.42

Long-Term Results in Hairy Cell Leukemia Treated with 2-Chlorodeoxyadenosine

Ladislav Chrobák^a, Pavel Žák^a, Karel Podzimek^b, Lenka Plíšková^c, Jaroslava Foglová^a, Vladimír Maisnar^a, Petr Dulíček^a, Karel Dědič^d

^aDepartment of Clinical Hematology, Charles University, Faculty of Medicine, Hradec Králové, Czech Republic
^bIst Department of Medicine, Charles University, Faculty of Medicine, Hradec Králové, Czech Republic
^cInstitute of Clinical Biochemistry and Diagnostics, Charles University, Faculty of Medicine, Hradec Králové, Czech Republic
^dDepartment of Pathological Anatomy, Charles University, Faculty of Medicine, Hradec Králové, Czech Republic

Received May 1, 1997
Accepted June 1, 1997

We treated 19 patients with hairy cell leukemia (HCL) with 2-chlorodeoxyadenosine. 15 patients followed up at least 6 months were evaluated. The follow up period varied between 6 months and 37 months (median, 19 months). 8 patients were previously treated. The overall response in 15 evaluable HCL patients was 100 %, with 87 % complete hematological remissions including three patients with retroperitoneal and mediastinal lymphadenopathy and one patient with leukemic infiltrates of the cornea; 13 % of patients achieved partial hematological remission. Soluble interleukin - 2 receptor (sIL-2R) considered as a reliable non-invasive marker of HCL tumor burden dropped from the median of 1350 pM/ml (range 188 to 9000 pM/ml) to the median of 84.3 pM/ml (range 37 to 382 pM/ml) RdW which reflects the anisocytosis of red cells decreased after therapy from the median of 20.6 % (range 13.1-25.0 %) to the median of 13.7 % (range 12.4-16.3 %).