Acta Med. 1997, 40: 3-8

https://doi.org/10.14712/18059694.2020.34

Effects of Repeated Administration of Dithiol Chelating Agent - Sodium 2,3-Dimercapto-1-propanesulphonate (DMPS) - On Biochemical and Haematological Parameters in Rabbits

Vladimír Geršla, Radomír Hrdinab, Jaroslava Vávrovác, Magdalena Holečkovác, Vladimír Paličkac, Jaroslava Voglovád, Yvona Mazurováe, Jiří Bajgarf

aDepartment of Pharmacology, Charles University, Faculty of Medicine, Hradec Králové, Czech Republic
bDepartment of Pharmacology and Toxicology, Charles University, Faculty of Pharmacy, Hradec Králové, Czech Republic
cInstitute of Clinical Biochemistry and Diagnostics, University Teaching Hospital, Hradec Králové, Czech Republic
dDepartment of Clinical Hematology, University Teaching Hospital, Hradec Králové, Czech Republic
eDepartment of Histology, Charles University, Faculty of Medicine, Hradec Králové, Czech Republic
fMilitary Medical Academy, Hradec Králové, Czech Republic

Received April 1, 1997
Accepted May 1, 1997

References

1. Aaseth J. Recent advance in the therapy of metal poisonings with chelating agents. Hum Toxicol 1983; 2:257-72. <https://doi.org/10.1177/096032718300200214>
2. Aposhian HV, Maiorino RM, Gonzalez-Ramirez D, Zuniga-Charles M, Xu Z, Hurlbut KM, Junco-Munoz P, Dart RC, Aposhian MM. Mobilization of haevy metals by newer, therapeutically useful chelating agents. Toxicology 1995; 97:23-38. <https://doi.org/10.1016/0300-483X(95)02965-B>
3. Benov LC, Benchev IC, Monovich OH. Thiol antidotes effect on lipid peroxidation in mercury-poisoned rats. Chem Biol Interact 1990; 76:321-32. <https://doi.org/10.1016/0009-2797(90)90099-9>
4. Benov LC, Ribarov SR, Monovich OH. Study of activated oxygen production by some thiols using chemiluminiscence. Gen Physiol Biophys 1992; 11:195-202.
5. Bocherens-Gadient SA, Quast U, Nussberger J, Brunner HR, Hof RP. Chronic adriamycin treatment and its effect on the cardiac b-adrenergic system in the rabbit. J Cardiovasc Pharmacol 1992; 19:770-8.
6. Bosque MA, Domingo JL, Paternain JL, Llobet JM, Corbella J. Evaluation of the developmental toxicity of 2,3-dimercapto-1-propanesulphonate (DMPS) in mice. Effect on mineral metabolism. Toxicology 1990; 62:311-20. <https://doi.org/10.1016/0300-483X(90)90054-K>
7. Coudray C, Boucher F, Deleiris J, Favier A. Modulation by selenium supplementation of lipid peroxidation induced by chronic administration of adriamycin in rats. Nutrition 1995; 11 (Suppl.):512-6.
8. Flora SJ, Dube SN, Arora U, Kannan GM, Shukla MK, Malhotra PR. Therapeutic potential of meso- 2,3-dimercaptosuccinic acid or 2,3-dimercaptopropane-1-sulphonate in chronic arsenic intoxication in rats. Biometals 1995; 8: 111-6. <https://doi.org/10.1007/BF00142009>
9. Gad SC, Weil Cs. Statistics for toxicologists. In: Hayes AW (ed). Principles and methods of toxicology. 2nd ed., New York:Raven Press, 1989;445-6.
10. Geršl V, Mazurová Y, Bajgar J, Mělka M, Hrdina R, Palička V. Lack of cardiotoxicity of a new antineoplastic agent, a synthetic derivative of indenoisochinoline: comparison with daunorubicin in rabbits. Arch Toxicol 1996; 70:645-51
11. Geršl V, Hrdina R. Noninvasive polygraphic cardiac changes in daunorubicin-induced cardiomyopathy in rabbits. Sb Ved Pr Lek Fak Univerzity Karlovy Hradec Králové 1994; 37:49-55.
12. Green MD, Alderton P, Gross J, Muggia FM, Speyer JL. Evidence of the selective alteration of anthracycline activity due to modulation by ICRF-187 (ADR-529). Pharmac Ther 1990; 48:61-9. <https://doi.org/10.1016/0163-7258(90)90018-W>
13. Haenen GRMM. Thiols in oxidative stress. Some implications for catecholamine toxicity. Amsterdam:Free University, 1990.182 pp.
14. Hurlbut KM, Maiorino RM, Mayersohn M, Dart RC, Bruce DC, Aposhian HV. Determination and metabolism of dithiol chelating agents. XVI. Pharmacokinetics of 2,3-dimercapto-1-propanesulphonate after intravenous administration to human volunteers. J Pharmacol Exp Ther 1994; 268:662-8.
15. Inns RH, Rice P. Efficacy of dimercapto chelating agents for the treatment of poisoning by percutaneously applied dichloro(2-chlorovinyl)arsine in rabbits. Hum Exp Toxicol 1993; 12:241-6. <https://doi.org/10.1177/096032719301200307>
16. Klimmek R, Krettek C, Werner HW. Acute effects of the haevy metal antidotes DMPS and DMSA on circulation, respiration, and blood homeostasis in dogs. Arch Toxicol 1993; 67:428-34. <https://doi.org/10.1007/BF01977405>
17. Kraus AL, Weisbroth SH, Flatt RE, Brewer N. Biology and diseases of rabbits. In: Fox JG, Cohen BJ, Loew FM, eds. Laboratory animal medicine. Orlando:Academic Press,1984:212-3.
18. Maiorino RM, Weber GL, Aposhian HV. Determination and metabolism of dithiol chelating agents. III. Formation of oxidized metabolites of 2,3-dimercaptopropane-1-sulfonic acid in rabbits. Drug Metab Dispos 1988; 16:455-63.
19. Planas-Bohne F, Gabard B, Schaffer EH. Toxicological studies on sodium 2,3-dimercaptopropane-1-sulphonate in the rat. Arzneimittel-Forsch 1980; 30:1291-4.
20. Seifert CF, Thompson DF, Nesser ME. Dexrazoxane in the prevention of doxorubicin-induced cardiotoxicity. Ann Pharmacother 1994; 28:1063-72. <https://doi.org/10.1177/106002809402800912>
21. Stewart JR, Diamond GL. In vivo renal tubular secretion and metabolism of the disulfide of 2,3-dimercaptopropane- 1-sulphonate. Drug Metab Dispos 1988; 16:189-95.
22. Szinicz L, Wiedemann P, Häring H, Weger N. Effects of repeated treatment with sodium 2,3-dimercaptopropane- 1-sulphonate in Beagle dogs. Arzneimittel-Forsch 1983; 33: 818-21.
23. Takahashi Y, Funakoshi T, Shimada H, Kojima S. The utility of chelating agents as antidotes for nephrotoxicity of gold sodium thiomalate in adjuvant-arthritic rats. Toxicology 1995; 97:151-7. <https://doi.org/10.1016/0300-483X(94)02944-P>
24. Van Vleet JF, Ferrans VJ. Evaluation of vitamin E and selenium protection against chronic adriamycin toxicity in rabbits. Cancer Treat Rep 1980; 64:315-7.
front cover

ISSN 1211-4286 (Print) ISSN 1805-9694 (Online)

Open access journal

Archive