Acta Med. 1997, 40: 3-8

https://doi.org/10.14712/18059694.2020.34

Effects of Repeated Administration of Dithiol Chelating Agent - Sodium 2,3-Dimercapto-1-propanesulphonate (DMPS) - On Biochemical and Haematological Parameters in Rabbits

Vladimír Geršla, Radomír Hrdinab, Jaroslava Vávrovác, Magdalena Holečkovác, Vladimír Paličkac, Jaroslava Voglovád, Yvona Mazurováe, Jiří Bajgarf

aDepartment of Pharmacology, Charles University, Faculty of Medicine, Hradec Králové, Czech Republic
bDepartment of Pharmacology and Toxicology, Charles University, Faculty of Pharmacy, Hradec Králové, Czech Republic
cInstitute of Clinical Biochemistry and Diagnostics, University Teaching Hospital, Hradec Králové, Czech Republic
dDepartment of Clinical Hematology, University Teaching Hospital, Hradec Králové, Czech Republic
eDepartment of Histology, Charles University, Faculty of Medicine, Hradec Králové, Czech Republic
fMilitary Medical Academy, Hradec Králové, Czech Republic

Received April 1, 1997
Accepted May 1, 1997

The effects of weekly intravenously administered a dithiol chelating agent - sodium 2,3-dimercaptopropanesulphonate (DMPS) - in a single dose of 50 mg/kg/week for 10 weeks on biochemical and haematological parameters were studied in rabbits. DMPS was well tolerated, an increase in body weight was similar in the DMPS-treated and control animals. DMPS caused significant decrease in plasma calcium and vitamin E concentrations at the end of the experiment. No significant differences in haematological parameters between the DMPS and control groups were observed. A significant decrease in magnesium content in myocardial tissue was observed in the DMPS-treated rabbits. The above-mentioned biochemical changes should be taken into account in studies of possible chelating and radical scavenging effects of DMPS in various pathological conditions.

Funding

This study was supported by means of Internal Grant of the Charles University No. 256/1994, and by IGA MH CR No. 4212-3/97.

References

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