Is Factor V Leiden a Risk Factor for Fetal Loss?

Dulíček, Petr; Chrobák, Ladislav; Kalousek, Ivo; Pešavová, Lenka; Pecka, Miroslav; Stránský, Pravoslav

doi:10.14712/18059694.2019.150

Acta Medica > Archive > 1999, Vol. 42 > Issue 3 > Is Factor V Leiden a Risk Factor for…

Acta Med. 1999, 42: 93-96

https://doi.org/10.14712/18059694.2019.150

Is Factor V Leiden a Risk Factor for Fetal Loss?

Petr Dulíček^a, Ladislav Chrobák^a, Ivo Kalousek^b, Lenka Pešavová^c, Miroslav Pecka^a, Pravoslav Stránský^d

^aUniversity Teaching Hospital in Hradec Králové, Department of Clinical Haematology, Hradec Králové, Czech Republic
^bCharles University in Prague, Faculty of Medicine in Hradec Králové, Department of Obstetrics and Gynecology, Hradec Králové, Czech Republic
^cUniversity Teaching Hospital in Hradec Králové, Department of Clinical Biochemistry, Hradec Králové, Czech Republic
^dCharles University in Prague, Faculty of Medicine in Hradec Králové, Department of Medical Biophysics, Hradec Králové, Czech Republic

Received September 1, 1999
Accepted September 1, 1999

A successful pregnancy is dependent on the development of adequate placental circulation. The abnormalities of placental vasculature may result in a number of gestational pathologies, including fetal loss. The aim of our study was to determine whether women with f V Leiden are at an increased risk of pregnancy loss. For this purpose we assessed three groups of women. In a prospective group we examined 30 females with spontaneous abortions for f V Leiden. In a retrospective group we assessed the frequency of abortions in 80 women (l72 pregnancies) with f V Leiden (72 heterozygous, 8 homozygous) from 57 unrelated families. In a control group we evaluated the frequency of abortions in 45 women without f V Leiden. Factor V Leiden was found in 3% of women in the 1st group. Fetal loss occurred in 10% of women in the 2nd group and in 9% in the 3rd group. Factor V Leiden was not found to be a risk factor for fetal loss in our study group.